Document Detail

Synergism between amikacin and cefazolin against Klebsiella: in vitro studies and effect on the bactericidal activity of serum.
MedLine Citation:
PMID:  977997     Owner:  NLM     Status:  MEDLINE    
Synergism between amikacin and cefazolin was studied in vitro in 20 strains of Klebsiella isolated from clinical material. Several techniques for the demonstration of synergism in vitro were employed. The checkerboard technique with use of bactericidal end points and the killing curves method showed synergism between amikacin and cefazolin for 13 and 15 strains, respectively. The two techniques were in accordance in 12 instances. The data obtained in vitro were correlated with the bactericidal activity in sera from 10 subjects who had received the usual doses of amikacin and cefazolin, alone or in combination. The sera of subjects who received amikacin plus cefazolin were bactericidal at significantly higher dilutions than sera of patients who received cefazolin alone. The increased serum bactericidal activity in subjects receiving amikacin plus cefazolin was observed only for strains against which these antibiotics were synergistic in vitro.
J Klastersky; F Meunier-Carpentier; J M Prevost; M Staquet
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  134     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  271-6     Citation Subset:  AIM; IM    
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MeSH Terms
Amikacin / pharmacology*
Blood Bactericidal Activity*
Cefazolin / pharmacology*
Cephalosporins / pharmacology*
Drug Evaluation
Drug Synergism
Kanamycin / analogs & derivatives*
Klebsiella / drug effects*
Middle Aged
Species Specificity
Reg. No./Substance:
0/Cephalosporins; 25953-19-9/Cefazolin; 37517-28-5/Amikacin; 59-01-8/Kanamycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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