Document Detail

Synergism between U.V. and thymidine treatments in the induction of cytogenetic damage in wild-type Friend erythroleukaemia cells.
MedLine Citation:
PMID:  3162754     Owner:  NLM     Status:  MEDLINE    
The cytogenetic aberration-inducing effect of excess thymidine and U.V. light in Friend erythroleukaemia (clone 707) cells was investigated. Three doses of U.V. were utilised, namely 2.4, 4.8 and 7.2 J/m2. Thymidine, at 1 X 10(-5) M, was present for 48 h prior to U.V. treatment and for 15 h following it. Although no significant increase in metaphase aberrations was observed following thymidine treatment alone, relative to the spontaneous frequency, clone 707 exhibited increased sensitivity to U.V.-induced cytogenetic damage, when grown in the presence of 1 X 10(-5) M thymidine. The observed synergism between U.V. and thymidine treatments may be due to thymidine-induced nucleotide pool imbalance with consequent inaccuracies in DNA repair.
V J McKelvey; P G McKenna
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia research     Volume:  12     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  1988  
Date Detail:
Created Date:  1988-05-26     Completed Date:  1988-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  IM    
Biomedical Sciences Research Centre, University of Ulster, Coleraine, Northern Ireland.
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MeSH Terms
Chromosome Aberrations*
Friend murine leukemia virus
Leukemia, Erythroblastic, Acute / genetics*,  pathology
Leukemia, Experimental / genetics*,  pathology
Thymidine / pharmacology*
Tumor Cells, Cultured / drug effects,  radiation effects
Ultraviolet Rays*
Reg. No./Substance:

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