Document Detail


Synergism between U.V. and thymidine treatments in the induction of cytogenetic damage in wild-type Friend erythroleukaemia cells.
MedLine Citation:
PMID:  3162754     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cytogenetic aberration-inducing effect of excess thymidine and U.V. light in Friend erythroleukaemia (clone 707) cells was investigated. Three doses of U.V. were utilised, namely 2.4, 4.8 and 7.2 J/m2. Thymidine, at 1 X 10(-5) M, was present for 48 h prior to U.V. treatment and for 15 h following it. Although no significant increase in metaphase aberrations was observed following thymidine treatment alone, relative to the spontaneous frequency, clone 707 exhibited increased sensitivity to U.V.-induced cytogenetic damage, when grown in the presence of 1 X 10(-5) M thymidine. The observed synergism between U.V. and thymidine treatments may be due to thymidine-induced nucleotide pool imbalance with consequent inaccuracies in DNA repair.
Authors:
V J McKelvey; P G McKenna
Related Documents :
2995974 - Uv-induced mutagenesis of phage s13 can occur in the absence of the reca and umuc prote...
23116714 - Shape string: a new feature for prediction of dna-binding residues.
6713404 - Dose response, wavelength dependence, and time course of ultraviolet radiation-induced ...
6373364 - Quantitative characterization of pyrimidine dimer excision from uv-irradiated dna (exci...
22228834 - Correction of rt-qpcr data for genomic dna-derived signals with validprime.
21465324 - The sequence selectivity of dna-targeted 9-aminoacridine cisplatin analogues in a telom...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia research     Volume:  12     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  1988  
Date Detail:
Created Date:  1988-05-26     Completed Date:  1988-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  IM    
Affiliation:
Biomedical Sciences Research Centre, University of Ulster, Coleraine, Northern Ireland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Aberrations*
Friend murine leukemia virus
Leukemia, Erythroblastic, Acute / genetics*,  pathology
Leukemia, Experimental / genetics*,  pathology
Mice
Thymidine / pharmacology*
Tumor Cells, Cultured / drug effects,  radiation effects
Ultraviolet Rays*
Chemical
Reg. No./Substance:
50-89-5/Thymidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Human AML colony growth in serum-free culture.
Next Document:  Thymidine kinase in human leukemia. Expression of the lymphoblastic isoenzyme in three patients with...