Document Detail

Synergism of CAY-1 with amphotericin B and itraconazole.
MedLine Citation:
PMID:  17008779     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: CAY-1 is a fungicidal saponin from cayenne pepper whose mode of action differs from amphotericin B (AB) and itraconazole (IT). This work determined CAY-1 synergism with AB or IT. METHODS: CAY-1 was purified and used in checkerboard microdilution studies where CAY-1 and AB or IT were mixed with nongerminated (NG) and germinating (G) conidia of three Aspergillus species and Candida albicans. Inhibition was visually determined at 24 and 48 h. RESULTS: CAY-1 had predominantly additive-synergistic interaction with AB or IT against the Aspergillus NG and G conidia. Excellent synergy between CAY-1 and AB occurred at 24 and 48 h against C. albicans. Results suggest CAY-1 enhances AB and IT efficacy.
A J De Lucca; J M Bland; S Boue; C B Vigo; T E Cleveland; T J Walsh
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Publication Detail:
Type:  Journal Article     Date:  2006-09-27
Journal Detail:
Title:  Chemotherapy     Volume:  52     ISSN:  0009-3157     ISO Abbreviation:  Chemotherapy     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-20     Completed Date:  2007-02-13     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0144731     Medline TA:  Chemotherapy     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  285-7     Citation Subset:  IM    
Southern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, New Orleans, La. 70124, USA.
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MeSH Terms
Amphotericin B / pharmacology*
Antifungal Agents / pharmacology*
Aspergillus flavus / drug effects
Aspergillus fumigatus / drug effects
Aspergillus niger / drug effects
Candida albicans / drug effects
Drug Combinations
Drug Resistance, Fungal / drug effects
Drug Synergism
Itraconazole / pharmacology*
Microbial Sensitivity Tests
Plant Preparations
Saponins / pharmacology*
Steroids / pharmacology*
Time Factors
Reg. No./Substance:
0/Antifungal Agents; 0/CAY-I; 0/Drug Combinations; 0/Plant Preparations; 0/Saponins; 0/Steroids; 1397-89-3/Amphotericin B; 84625-61-6/Itraconazole

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