Document Detail

Synergic effects of kallikrein-kinin and prostaglandins on renin release on infusion of isolated hog kidney with aldosterone.
MedLine Citation:
PMID:  6203005     Owner:  NLM     Status:  MEDLINE    
The effects of infusion of a large amount of aldosterone into the renal artery of isolated perfused hog kidney on the release of renin, prostaglandins (PG) and kinin and the excretion of urinary kallikrein were investigated. Infusion of aldosterone at a rate of 100 ng/min (100 to 800 ng/ml of perfusate) resulted in significant releases of renin, PG (PGE2 , 6-0-PGF1 alpha), and kinin and increase in urinary kallikrein. Infusion of aldosterone and an inhibitor of kallikrein, aprotinin, decreased the releases of renin, PG and kinin and infusion of aldosterone with indomethacin decreased the release of PG but increased that of kinin and urinary kallikrein without significant change in renin releases. These findings suggest that the release of renin by aldosterone may result from synergic effects of renal PG and the kallikrein -kinin system.
S Gotoh; T Ogihara; M Nakamaru; H Ohde; J Higaki; A Otsuka; Y Tabuchi; Y Kumahara; T Nishino
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  34     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-07-09     Completed Date:  1984-07-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1913-8     Citation Subset:  IM    
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MeSH Terms
Aldosterone / pharmacology*
Aprotinin / pharmacology
Indomethacin / pharmacology
Kallikreins / physiology*
Kidney / secretion*
Kinins / physiology*
Prostaglandins / physiology*,  secretion
Renin / secretion*
Reg. No./Substance:
0/Kinins; 0/Prostaglandins; 52-39-1/Aldosterone; 53-86-1/Indomethacin; 9087-70-1/Aprotinin; EC 3.4.21.-/Kallikreins; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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