| Synergic effect of phytoestrogens and exercise training on cardiovascular risk profile in exercise-responder postmenopausal women: a pilot study. | |
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MedLine Citation:
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PMID: 20539245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We showed that isoflavones and exercise improve total and abdominal fat mass (FM) to a greater extent than does exercise alone in postmenopausal women, but not other cardiovascular disease (CVD) risk factors. Fat-free mass (FFM) showed a wide variability of responses, with 60% of women having increased FFM and 40% having decreased FFM. We thus wondered if women who had decreased FFM could be considered as nonresponders (NRs) to exercise and if this masked a potential synergistic effect of phytoestrogens (PHY) and exercise. The aim of this study was to verify if PHYs enhance the response obtained after aerobic and resistance exercises in CVD risk profile in exercise responders. METHODS: Among 21 women who participated in a 6-month exercise program and received PHY or placebo (PLA), 14 were exercise responders (PHY, n = 8; PLA, n = 6) whereas 7 were NRs. Body weight, waist circumference, FM, and FFM were assessed (dual-energy x-ray absorptiometry). Plasma glucose, insulin, sex hormone-binding globulin, and testosterone levels were obtained after a 12-hour overnight fast. Total energy intake was measured with a 3-day dietary record. All measurements were performed before and after the intervention. RESULTS: After exercise training, the PHY and PLA groups, but not the NR group, had increased FFM (0.01 < P < 0.03). On the other hand, body weight, FM, and systolic and diastolic blood pressure (0.01 < P < 0.05) decreased in the PHY group only. Furthermore, plasma insulin level (P = 0.04) and homeostasis model assessment significantly decreased (P = 0.03) while plasma sex hormone-binding globulin increased (P = 0.04) after training in the PHY group, whereas energy intake remained unchanged in both groups (0.10 < P < 0.59) after the intervention. CONCLUSION: PHYs combined with exercise compared with exercise alone seem to improve body composition and CVD risk profile in exercise-responder women. |
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Authors:
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Eléonor Riesco; Mylène Aubertin-Leheudre; Mathieu L Maltais; Mélisa Audet; Isabelle J Dionne |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: 17 ISSN: 1530-0374 ISO Abbreviation: Menopause Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-09-14 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: United States |
Other Details:
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Languages: eng Pagination: 1035-9 Citation Subset: IM |
Affiliation:
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Faculty of Physical Education and Sports, University of Sherbrooke, Sherbrooke, Quebec, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Fat* Combined Modality Therapy Double-Blind Method Exercise Therapy* Female Humans Isoflavones / therapeutic use* Middle Aged Phytoestrogens / therapeutic use* Pilot Projects Postmenopause* Weight Loss |
| Grant Support | |
ID/Acronym/Agency:
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//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Isoflavones; 0/Phytoestrogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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