| The Synergic Effect of Regular Exercise and Resveratrol on Kainate-Induced Oxidative Stress and Seizure Activity in Mice. | |
| | |
MedLine Citation:
|
PMID: 23054073 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The synergic effect of regular exercise and resveratrol, a polyphenolic compound with potent antioxidant activity, was investigated against kainate-induced seizures and oxidative stress in mice. After 6 weeks of swimming training, the total body weight decreased and the blood concentration of lactate stabilized statistically in comparison with the sedentary mice, indicate that the training program increased the aerobic resistance of mice. Kainate (30 mg/kg) evoked seizure activity 5 min after injection, and seizure activity was measured seizure rating scores every 5 min up to 2 h. As previously well known experiments, regular exercise and resveratrol (40 mg/kg, daily supplementation for 6 weeks) have an inhibitory effect on kainate-induced seizure activity and oxidative stress. In particularly, a synergistic cooperation of regular exercise and resveratrol was observed in seizure activity, mortality and oxidative stress especially in SOD activity. These results suggest that regular exercise along with an anti-convulsant agent such as resveratrol could be a more efficient method for the prevention of seizure development than exercise alone. |
| | |
Authors:
|
Hee-Jae Kim; Il-Kon Kim; Wook Song; Jin Lee; Sok Park |
Related Documents
:
|
19515923 - Exercise induces cortical plasticity after neonatal spinal cord injury in the rat. 21794933 - The pathophysiology of heart failure with preserved ejection fraction: from molecular m... 1757323 - Fluid replacement and glucose infusion during exercise prevent cardiovascular drift. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-4 |
Journal Detail:
|
Title: Neurochemical research Volume: - ISSN: 1573-6903 ISO Abbreviation: Neurochem. Res. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Health and Exercise Science Laboratory, Institute of Sports Science, Seoul National University, Seoul, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Low-Dose Sarin Exposure Produces Long Term Changes in Brain Neurochemistry of Mice.
Next Document: Functional Annotation of Genes Differentially Expressed Between Primary Motor and Prefrontal Associa...