Document Detail


The synergic effect of regular exercise and resveratrol on kainate-induced oxidative stress and seizure activity in mice.
MedLine Citation:
PMID:  23054073     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synergic effect of regular exercise and resveratrol, a polyphenolic compound with potent antioxidant activity, was investigated against kainate-induced seizures and oxidative stress in mice. After 6 weeks of swimming training, the total body weight decreased and the blood concentration of lactate stabilized statistically in comparison with the sedentary mice, indicate that the training program increased the aerobic resistance of mice. Kainate (30 mg/kg) evoked seizure activity 5 min after injection, and seizure activity was measured seizure rating scores every 5 min up to 2 h. As previously well known experiments, regular exercise and resveratrol (40 mg/kg, daily supplementation for 6 weeks) have an inhibitory effect on kainate-induced seizure activity and oxidative stress. In particularly, a synergistic cooperation of regular exercise and resveratrol was observed in seizure activity, mortality and oxidative stress especially in SOD activity. These results suggest that regular exercise along with an anti-convulsant agent such as resveratrol could be a more efficient method for the prevention of seizure development than exercise alone.
Authors:
Hee-jae Kim; Il-Kon Kim; Wook Song; Jin Lee; Sok Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-04
Journal Detail:
Title:  Neurochemical research     Volume:  38     ISSN:  1573-6903     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-20     Completed Date:  2013-05-29     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  117-22     Citation Subset:  IM    
Affiliation:
Health and Exercise Science Laboratory, Institute of Sports Science, Seoul National University, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Anaerobic Threshold / drug effects,  physiology
Animals
Antioxidants / pharmacology*
Body Weight / drug effects,  physiology
Catalase / metabolism
Kainic Acid / pharmacology*
Lactic Acid / metabolism
Male
Mice
Mice, Inbred ICR
Oxidative Stress / drug effects*
Physical Conditioning, Animal / physiology*
Seizures / chemically induced*,  physiopathology,  prevention & control*
Stilbenes / pharmacology*
Superoxide Dismutase / metabolism
Swimming / physiology
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Stilbenes; 487-79-6/Kainic Acid; 50-21-5/Lactic Acid; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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