| Syndromes of nonfluent primary progressive aphasia: a clinical and neurolinguistic analysis. | |
| | |
MedLine Citation:
|
PMID: 20713949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Despite recent work, the nosology of nonfluent primary progressive aphasia (PPA) remains unresolved. METHODS: We describe a clinical and neurolinguistic cross-sectional analysis of a cohort of 24 patients with nonfluent PPA. Patients were initially classified based on analysis of spontaneous speech into 4 groups: apraxia of speech (AOS)/agrammatism (10 patients); AOS/no agrammatism (4 patients); no AOS/agrammatism (3 patients); no AOS/no agrammatism (7 patients). These groups were further characterized using a detailed neurolinguistic and neuropsychological battery. Parkinsonism was present in 3/10 patients in the AOS/agrammatism group. All patients in the no AOS/agrammatism group had mutations in the progranulin (GRN) gene, while 5/7 cases in the no AOS/no agrammatism group had CSF findings compatible with Alzheimer disease. RESULTS: The groups without AOS showed more severe neurolinguistic impairments for a given disease stage, and sentence comprehension, speech repetition, and reading were impaired in all groups. Prolonged word-finding pauses and impaired single word comprehension were salient features in the no AOS/agrammatism group. Additional impairments of executive function and praxis were present in both groups with agrammatism, and impaired episodic memory was a feature of the no AOS/no agrammatism group. CONCLUSION: PPA with AOS is aligned with the syndrome previously designated progressive nonfluent aphasia; agrammatism may emerge as the syndrome evolves, or alternatively, the pure AOS group may be pathophysiologically distinct. PPA without AOS resembles the syndrome designated logopenic/phonologic aphasia; however, there is evidence for a distinct subsyndrome of GRN-associated aphasia. The findings provide a rationale for further longitudinal studies with pathologic correlation. |
| | |
Authors:
|
Jonathan D Rohrer; Martin N Rossor; Jason D Warren |
Related Documents
:
|
8997549 - Intracerebroventricular administration of gm1 ganglioside to presenile alzheimer patients. 20491609 - Effect of brain-derived neurotrophic factor val66met polymorphism and serum levels on t... 8422739 - A predictor for side effects in patients with alzheimer's disease treated with deferoxa... 8544899 - Alzheimer pathology of patients carrying apolipoprotein e epsilon 4 allele. 11493169 - Basal ganglia metabolite abnormalities in minor motor disorders associated with human i... 10973599 - Visual feedback has differential effects on reaching movements in parkinson's and alzhe... 20037859 - Is tin fume exposure benign or not? two case reports. 2926269 - Chronic aspiration and laryngeal competence. 19833379 - Bolus tenecteplase for right ventricle dysfunction in hemodynamically stable patients w... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neurology Volume: 75 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-17 Completed Date: 2010-09-13 Revised Date: 2011-08-25 |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
|
Languages: eng Pagination: 603-10 Citation Subset: AIM; IM |
Affiliation:
|
Dementia Research Centre, Institute of Neurology, Queen Square, London WC1N 3BG, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Aphasia, Broca / physiopathology Cognition Disorders / complications Cohort Studies Cross-Sectional Studies Executive Function / physiology* Female Humans Linguistics* Male Middle Aged Neurologic Examination Neuropsychological Tests Primary Progressive Nonfluent Aphasia / classification, physiopathology*, psychology* Severity of Illness Index Speech / physiology Verbal Learning / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
//Medical Research Council; //Wellcome Trust |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multimodal predictors for Alzheimer disease in nonfluent primary progressive aphasia.
Next Document: HLA B*44: protective effects in MS susceptibility and MRI outcome measures.