Document Detail


Syndromes of ketosis-prone diabetes mellitus.
MedLine Citation:
PMID:  18292467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ketosis-prone diabetes (KPD) is a widespread, emerging, heterogeneous syndrome characterized by patients who present with diabetic ketoacidosis or unprovoked ketosis but do not necessarily have the typical phenotype of autoimmune type 1 diabetes. Multiple, severe forms of beta-cell dysfunction appear to underlie the pathophysiology of KPD. Until recently, the syndrome has lacked an accurate, clinically relevant and etiologically useful classification scheme. We have utilized a large, longitudinally followed, heterogeneous, multiethnic cohort of KPD patients to identify four clinically and pathophysiologically distinct subgroups that are separable by the presence or absence of beta-cell autoimmunity and the presence or absence of beta-cell functional reserve. The resulting "Abeta" classification system of KPD has proven to be highly accurate and predictive of such clinically important outcomes as glycemic control and insulin dependence, as well as an aid to biochemical and molecular investigations into novel causes of beta-cell dysfunction. In this review, we describe the current state of knowledge in regard to the natural history, pathophysiology, and treatment of the subgroups of KPD, with an emphasis on recent advances in understanding their immunological and genetic bases.
Authors:
Ashok Balasubramanyam; Ramaswami Nalini; Christiane S Hampe; Mario Maldonado
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-02-21
Journal Detail:
Title:  Endocrine reviews     Volume:  29     ISSN:  0163-769X     ISO Abbreviation:  Endocr. Rev.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-15     Completed Date:  2008-07-28     Revised Date:  2013-03-11    
Medline Journal Info:
Nlm Unique ID:  8006258     Medline TA:  Endocr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  292-302     Citation Subset:  IM    
Affiliation:
Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Room 700B, One Baylor Plaza, and Endocrine Service, Ben Taub General Hospital, Houston, Texas 77030, USA. ashokb@bcm.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Diabetes Mellitus, Type 1 / classification*,  physiopathology*,  therapy
Female
Humans
Insulin-Secreting Cells / physiology*
Male
Middle Aged
Syndrome*
Grant Support
ID/Acronym/Agency:
R01 HL73969/HL/NHLBI NIH HHS
Comments/Corrections

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