| Syndrome of inappropriate antidiuresis may herald or accompany neuromyelitis optica. | |
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MedLine Citation:
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PMID: 21998320 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aquaporin-4 (AQP4) is the target autoantigen of an immunoglobulin G (IgG) autoantibody that distinguishes a spectrum of inflammatory demyelinating CNS disorders (the neuromyelitis optica [NMO] spectrum) from multiple sclerosis (MS) and other CNS demyelinating disorders.(1) Compelling evidence supports this IgG having a central role in the pathogenesis of NMO. AQP4 is concentrated in astrocytic foot processes at interfaces between CNS parenchyma and fluid compartments, both CSF and blood,(1) and in areas involved in osmosensitivity and osmoregulation, including supraoptic and paraventricular nuclei of the hypothalamus and sensory circumventricular organs, the subfornical organ, the organum vasculosum of the lamina terminalis, and the area postrema.(2) A single case of the syndrome of inappropriate antidiuresis (SIAD) has been described in NMO.(3) Here we report the frequency of SIAD in NMO. |
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Authors:
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R Iorio; C F Lucchinetti; V A Lennon; C Costanzi; S Hinson; B G Weinshenker; S J Pittock |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-12 |
Journal Detail:
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Title: Neurology Volume: - ISSN: 1526-632X ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Departments of Laboratory Medicine and Pathology (R.I., V.A.L., S.H., S.J.P.), Neurology (R.I., C.F.L., V.A.L., C.C., B.G.W., S.J.P.), and Immunology (V.A.L.), Mayo Clinic College of Medicine, Rochester, MN. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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