Document Detail


Sjögren's Syndrome: An Update on Epidemiology and Current Insights on Pathophysiology.
MedLine Citation:
PMID:  24287189     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Primary Sjögren's syndrome (pSS) is an autoimmune chronic inflammatory disorder affecting 0.2% to 3.0% of the population, with a 9:1 female to male ratio. Features are oral and ocular dryness, local and systemic autoantibody production, and progressive focal mononuclear cell infiltration in the affected salivary and lacrimal glands. Lymphoma is the most severe complication of pSS, occurring in 4% to 5% of patients. Genetic studies identified an association with HLA and susceptibility genes in cytokine genes and genes involved in B-cell differentiation. Genetic variations may help explain why disease manifestations differ among patients and supports the hypothesis of certain distinct disease phenotypes.
Authors:
Tove R Reksten; Malin V Jonsson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral and maxillofacial surgery clinics of North America     Volume:  26     ISSN:  1558-1365     ISO Abbreviation:  Oral Maxillofac Surg Clin North Am     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2013-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001454     Medline TA:  Oral Maxillofac Surg Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-12     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
Affiliation:
Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, The Laboratory Building, 5th Floor, Haukeland University Hospital, Bergen N-5021, Norway.
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