Document Detail

The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT): one-year follow-up of a single case.
MedLine Citation:
PMID:  19046589     Owner:  NLM     Status:  MEDLINE    
In this article, we report the case history of a 44-year-old female patient with bipolar disorder who developed the so-called Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT). A detailed description of our patient's neurologic status is provided at baseline (i.e. during lithium intoxication) and after one year of follow-up, confirming the persistency of cerebellar signs and symptoms. Although rare, our report - which shows a severe and disabling form of SILENT - underscores the need to perform a strict control of the putative risk factors argued to be associated with the development of this syndrome. In our case, the presence of fever and the administration of multiple doses of antipsychotics may have contributed to the poor outcome exhibited by the patient.
Fábio H G Porto; Marco A A Leite; Leonardo F Fontenelle; Rogério P Marrocos; Natália F Szczerback; Marcos R G de Freitas
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-11-30
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  277     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-04-02     Revised Date:  2009-05-08    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  172-3     Citation Subset:  IM    
Federal Fluminense University, Miguel de Frias 245, bl 3 apt 601, Niterói, Rio de Janeiro, 24220-005, Brazil.
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MeSH Terms
Antimanic Agents / adverse effects*
Bipolar Disorder / drug therapy*
Cerebellar Diseases / chemically induced*
Lithium Compounds / adverse effects*
Neurotoxicity Syndromes / etiology*
Reg. No./Substance:
0/Antimanic Agents; 0/Lithium Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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