Document Detail

Syncytial giant-cell hepatitis due to autoimmune hepatitis type II (LKM1+) presenting as subfulminant hepatitis.
MedLine Citation:
PMID:  10710079     Owner:  NLM     Status:  MEDLINE    
Giant cell hepatitis (GCH) in adults is a rare event. The diagnosis of GCH is based on findings of syncytial giant hepatocytes. It is commonly associated with either viral infection or autoimmune hepatitis type I. A patient with GCH due to autoimmune hepatitis type II (LKM1+) is described, a combination that has not been previously reported. Corticosteroid therapy was effective in decreasing serum liver enzymes; however, the patient deteriorated rapidly and developed subfulminant hepatic failure. Although an emergency orthotopic liver transplantation was performed, the patient died because of reperfusion injury. Interestingly, only a few giant hepatocytes were noted in the explanted liver. This case stresses the association of GCH with autoimmune disorders, the possible immune mechanism involved in the formation of giant cell hepatocytes, and illustrates the rapidly progressive course and unfavorable prognosis that these patients can develop.
Z Ben-Ari; E Broida; Y Monselise; A Kazatsker; J Baruch; O Pappo; E Skappa; R Tur-Kaspa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  95     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-03-21     Completed Date:  2000-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  799-801     Citation Subset:  IM    
Liver Institute, Department of Medicine D, Rabin Medical Center, Petah Tiqva, Israel.
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MeSH Terms
Autoantibodies / analysis*
Diagnosis, Differential
Fatal Outcome
Giant Cells* / pathology
Hepatitis, Autoimmune / diagnosis*,  pathology
Liver / pathology
Liver Failure / diagnosis*,  pathology
Liver Function Tests
Liver Transplantation
Middle Aged
Reg. No./Substance:
0/Autoantibodies; 0/anti-liver kidney microsome antibody

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