| Syncope caused by hyperkalemia during use of a combined therapy with the angiotensin-converting enzyme inhibitor and spironolactone. | |
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MedLine Citation:
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PMID: 20859899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 76 year-old woman with a history of coronary artery bypass grafting and prior myocardial infarction was transferred to the emergency room with loss of consciousness due to marked bradycardia caused by hyperkalemia. The concentration of serum potassium was high, and normal sinus rhythm was restored after correction of the serum potassium level. The cause of hyperkalemia was considered to be several doses of spiranolactone, an aldosterone antagonist, in addition to the long-term intake of ramipril, an ACE inhibitor. This case is a good example of electrolyte imbalance causing acute life-threatening cardiac events. Clinicians should be alert to the possibility of hyperkalemia, especially in elderly patients using ACE/ARB in combination with potassium sparing agents and who have mild renal disturbance. |
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Authors:
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Ismail Erden; Subhan Yalcin; Hakan Ozhan |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Kardiologia polska Volume: 68 ISSN: 0022-9032 ISO Abbreviation: Kardiol Pol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-22 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376352 Medline TA: Kardiol Pol Country: Poland |
Other Details:
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Languages: eng Pagination: 1043-5; discussion 1046 Citation Subset: IM |
Affiliation:
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Department of Cardiology Duzce Medicine Faculty, Duzce University, Duzce, Turkey. iserdemus@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aldosterone Antagonists / adverse effects Angiotensin-Converting Enzyme Inhibitors / administration & dosage, adverse effects* Antihypertensive Agents / adverse effects Diuretics / adverse effects Drug Therapy, Combination Female Heart Failure / drug therapy Humans Hyperkalemia / chemically induced*, diagnosis*, prevention & control Hypertension / drug therapy Spironolactone / administration & dosage, adverse effects* Syncope / chemically induced*, diagnosis*, prevention & control Water-Electrolyte Balance |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Diuretics; 52-01-7/Spironolactone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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