Document Detail


Syncope caused by hyperkalemia during use of a combined therapy with the angiotensin-converting enzyme inhibitor and spironolactone.
MedLine Citation:
PMID:  20859899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 76 year-old woman with a history of coronary artery bypass grafting and prior myocardial infarction was transferred to the emergency room with loss of consciousness due to marked bradycardia caused by hyperkalemia. The concentration of serum potassium was high, and normal sinus rhythm was restored after correction of the serum potassium level. The cause of hyperkalemia was considered to be several doses of spiranolactone, an aldosterone antagonist, in addition to the long-term intake of ramipril, an ACE inhibitor. This case is a good example of electrolyte imbalance causing acute life-threatening cardiac events. Clinicians should be alert to the possibility of hyperkalemia, especially in elderly patients using ACE/ARB in combination with potassium sparing agents and who have mild renal disturbance.
Authors:
Ismail Erden; Subhan Yalcin; Hakan Ozhan
Related Documents :
1031999 - Features of lysosomal proteolytic enzyme activity in infarcted myocardium.
19804149 - Cardiac markers in acute coronary syndrome.
3715799 - The co-operative action of hyaluronidase and urokinase on the isoproterenol-induced myo...
2337989 - Heterogeneity of creatine kinase isoenzyme mm in serum in myocardial infarction: interc...
18298349 - Serum levels of the osteoprotegerin, receptor activator of nuclear factor kappa-b ligan...
3559189 - The effects of personal interaction on triglyceride and uric acid levels, and coronary ...
878909 - Factors modifying ischemic injury in the isolated rat heart.
489819 - The relationship between collagen and ultrasonic attenuation in myocardial tissue.
19632519 - Impact of intravenous immunoglobulin infusion on longitudinal left ventricular performa...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Kardiologia polska     Volume:  68     ISSN:  0022-9032     ISO Abbreviation:  Kardiol Pol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-22     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376352     Medline TA:  Kardiol Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  1043-5; discussion 1046     Citation Subset:  IM    
Affiliation:
Department of Cardiology Duzce Medicine Faculty, Duzce University, Duzce, Turkey. iserdemus@yahoo.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aldosterone Antagonists / adverse effects
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  adverse effects*
Antihypertensive Agents / adverse effects
Diuretics / adverse effects
Drug Therapy, Combination
Female
Heart Failure / drug therapy
Humans
Hyperkalemia / chemically induced*,  diagnosis*,  prevention & control
Hypertension / drug therapy
Spironolactone / administration & dosage,  adverse effects*
Syncope / chemically induced*,  diagnosis*,  prevention & control
Water-Electrolyte Balance
Chemical
Reg. No./Substance:
0/Aldosterone Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Diuretics; 52-01-7/Spironolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Boerhaave's syndrome - a difficult differential diagnosis of chest pain.
Next Document:  [ST-segment elevation myocardial infarction due to anaphylactic shock triggered by contrast medium].