| Synchrotron X-ray analyses demonstrate phosphate-bound gadolinium in skin in nephrogenic systemic fibrosis. | |
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MedLine Citation:
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PMID: 20560953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Nephrogenic systemic fibrosis (NSF) is an incurable, debilitating disease found exclusively in patients with decreased kidney function and comprises a fibrosing disorder of the skin and systemic tissues. The disease is associated with exposure to gadolinium (Gd)-based contrast agents (GBCA) used in magnetic resonance imaging (MRI). Tissue samples from many patients with NSF contain micron-sized insoluble Gd-containing deposits. However, the precise composition and chemical nature of these particles is unclear. OBJECTIVES: To clarify the precise chemical structure of the Gd-containing deposits in NSF tissues. METHODS: Autopsy skin tissues from a patient with NSF were examined in situ using synchrotron X-ray fluorescence (SXRF) microscopy and extended X-ray absorption fine structure (EXAFS) spectroscopy and in correlation with light microscopy and the results of scanning electron microscopy /energy dispersive spectroscopy analyses. RESULTS: The insoluble Gd deposits were shown to contain Gd no longer coordinated by GBCA chelator molecules but rather in a sodium calcium phosphate material. SXRF microscopy shows a clear correlation between Gd, Ca and P. EXAFS spectroscopy shows a very different spectrum from the GBCAs, with Gd–P distances at 3·11 A and 3·11 A as well as Gd–Gd distances at an average of 4·05 A, consistent with a GdPO4 structure. CONCLUSIONS: This is the first direct evidence for the chemical release of Gd from GBCA in human tissue. This supports the physical–chemical, clinical and epidemiological data indicating a link between stability and dose of GBCA to the development of NSF. |
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Authors:
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S J George; S M Webb; J L Abraham; S P Cramer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The British journal of dermatology Volume: 163 ISSN: 1365-2133 ISO Abbreviation: Br. J. Dermatol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-03 Completed Date: 2011-01-10 Revised Date: 2011-09-22 |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 1077-81 Citation Subset: IM |
Affiliation:
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Department of Applied Science, University of California, Davis, CA 95616, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autopsy Calcium / analysis Gadolinium / analysis* Humans Magnetic Resonance Imaging Male Middle Aged Nephrogenic Fibrosing Dermopathy / etiology, metabolism*, pathology Phosphates / analysis Skin / chemistry*, pathology Spectrometry, Fluorescence / methods* Synchrotrons |
| Grant Support | |
ID/Acronym/Agency:
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EB-001962/EB/NIBIB NIH HHS; GM-65440/GM/NIGMS NIH HHS; R01 EB001962-15/EB/NIBIB NIH HHS; R01 GM065440-08/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phosphates; 7440-54-2/Gadolinium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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