| Synchronous growth of Escherichia coli after treatment with fluorophenylalanine. | |
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MedLine Citation:
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PMID: 4892375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of exponentially growing Escherichia coli cells with the amino acid analogue, p-fluorophenylalanine (FPA), resulted in a decrease in the amount of deoxyribonucleic acid (DNA) present per cell. A minimum DNA content per cell was reached approximately 80 min after addition of FPA to the culture. After this time the DNA per cell rose to the level of the untreated cell. When an FPA-treated culture was resuspended in fresh medium containing no FPA 80 min after addition of the analogue, the increases in cell number and DNA became synchronous. Ribonucleic acid was synthesized immediately and continuously throughout the cell cycle, except during periods of DNA synthesis and cell division. |
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Authors:
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M A Brostrom; S B Binkley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of bacteriology Volume: 98 ISSN: 0021-9193 ISO Abbreviation: J. Bacteriol. Publication Date: 1969 Jun |
Date Detail:
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Created Date: 1969-08-07 Completed Date: 1969-08-07 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985120R Medline TA: J Bacteriol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1271-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Division* DNA, Bacterial / metabolism Escherichia coli / drug effects*, growth & development, metabolism Phenylalanine / pharmacology* RNA, Bacterial / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/DNA, Bacterial; 0/RNA, Bacterial; 63-91-2/Phenylalanine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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