Document Detail

Synchronous growth of Escherichia coli after treatment with fluorophenylalanine.
MedLine Citation:
PMID:  4892375     Owner:  NLM     Status:  MEDLINE    
Treatment of exponentially growing Escherichia coli cells with the amino acid analogue, p-fluorophenylalanine (FPA), resulted in a decrease in the amount of deoxyribonucleic acid (DNA) present per cell. A minimum DNA content per cell was reached approximately 80 min after addition of FPA to the culture. After this time the DNA per cell rose to the level of the untreated cell. When an FPA-treated culture was resuspended in fresh medium containing no FPA 80 min after addition of the analogue, the increases in cell number and DNA became synchronous. Ribonucleic acid was synthesized immediately and continuously throughout the cell cycle, except during periods of DNA synthesis and cell division.
M A Brostrom; S B Binkley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bacteriology     Volume:  98     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1969 Jun 
Date Detail:
Created Date:  1969-08-07     Completed Date:  1969-08-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1271-3     Citation Subset:  IM    
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MeSH Terms
Cell Division*
DNA, Bacterial / metabolism
Escherichia coli / drug effects*,  growth & development,  metabolism
Phenylalanine / pharmacology*
RNA, Bacterial / biosynthesis
Reg. No./Substance:
0/DNA, Bacterial; 0/RNA, Bacterial; 63-91-2/Phenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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