| Synchronous delivery systems composed of Au nanoparticles and stimuli-sensitive diblock terpolymer. | |
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MedLine Citation:
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PMID: 15747181 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A method to construct synchronous delivery systems via direct self-assembly of Au nanoparticles on the poly[(N-isopropylacrylamide-r-acrylamide)-b-L-lactic acid] (PNAL) nanospheres has been presented in this paper. To achieve amphiphilic diblock terpolymer, hydrophobic poly (L-lactic acid) (PLLA) block was added to poly(N-isopropylacrylamide- r-acrylamide) (PNA) block via Michel-type addition reaction. Lower critical solubility temperature (LCST) was modulated at 35.6 degrees C which is close to the body temperature, but higher than poly(N-isopropylacrylamide) (PNIPAAm) homopolymer by controlling the ratio between isopropylacrylamide (IPAAm) monomers and acrylamide (AAm) monomers. Using this amphiphilic diblock terpolymer, PNAL nanospheres were fabricated by emulsion/evaporation technique followed by direct self-assembly of Au nanoparticles on the PNAL nanospheres due to the high affinity of amino groups donated from PNA block. The 'core' site of Au@PNAL nanospheres can load various lyphophilic drugs. Moreover, Au nanoparticles in the 'shell' domain of PNAL nanospheres give optimal environment to conjugate various biomolecules. Therefore, it is expected that Au@PNAL hybrid nanospheres can be utilized in synchronous delivery of both biomolecules in the 'shell' domain and various therapeutic drugs in the 'core' domain. |
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Authors:
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Y S Jo; D K Kim; M Muhammed |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of materials science. Materials in medicine Volume: 15 ISSN: 0957-4530 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2005-03-04 Completed Date: 2005-06-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
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Languages: eng Pagination: 1291-5 Citation Subset: IM |
Affiliation:
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Materials Chemistry Division, Royal Institute of Technology, Stockholm, SE, 100 44, Sweden. yunsuk@met.kth.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acrylic Resins
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chemistry* Gold / chemistry* Magnetic Resonance Spectroscopy Nanotechnology Particle Size |
| Chemical | |
Reg. No./Substance:
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0/Acrylic Resins; 0/poly(N-isopropylacrylamide-co-acrylamide); 7440-57-5/Gold |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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