| Synchronous angiosarcoma, melanoma and morphea of the breast skin 14 years after radiotherapy for mammary carcinoma. | |
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MedLine Citation:
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PMID: 20526547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With the improvement in survival after breast cancer there has been increasing interest in the long-term effects of radiotherapy, including the development of tumours. Compared with the general population, breast cancer survivors have a 10-50% higher risk of developing a second cancer. Radiotherapy may play a role in the onset of such lesions. We describe here the case of a 68-year-old woman who developed synchronous cutaneous angiosarcoma, melanoma and morphea of the breast skin and the local area, 14 years after radiotherapy for breast carcinoma. Given the risk of post-radiation secondary primaries in breast cancer patients, long-term surveillance is necessary, with particular attention being paid to skin changes in the irradiation field. Radiation-induced morphea is a rare complication in which immunological abnormalities may stimulate malignant transformation. Long-term studies are required to clarify the pathogenesis of these rare associations. |
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Authors:
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Vincenzo de Giorgi; Raffaella Santi; Marta Grazzini; Federica Papi; Alessia Gori; Susanna Rossari; Daniela Massi; Torello Lotti |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 90 ISSN: 1651-2057 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-07 Completed Date: 2010-09-07 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: Sweden |
Other Details:
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Languages: eng Pagination: 283-6 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of Florence, IT-50121 Firenze, Italy. vincenzo.degiorgi@unifi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Breast Neoplasms / radiotherapy* Carcinoma / radiotherapy* Female Hemangiosarcoma / etiology*, pathology Humans Melanoma / etiology*, pathology Neoplasms, Radiation-Induced / etiology*, pathology Neoplasms, Second Primary / etiology*, pathology Radiotherapy / adverse effects Scleroderma, Localized / etiology*, pathology Skin / pathology, radiation effects Skin Neoplasms / etiology*, pathology Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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