Document Detail


Synchronized changing of transinterface pressure, bubble radius and surface tension: a unique feature of lung surfactant.
MedLine Citation:
PMID:  9353902     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pulsating bubble surfactometer has been commonly used to measure the minimum surface tension of lung surfactant. The complexity of the original transinterface pressure tracings and its possible physiological meanings remain undefined. In the present study, we compared surface properties between calf lung surfactant extract (CLSE) and Tween 20, a nonionic surfactant, with the pulsating bubble surfactometer. A synchronized change between transinterface pressure (P) and bubble radius (R) was observed when CLSE was tested. Mathematical analysis and computer simulation indicate that this is due to the extremely potent surface tension lowering and adjusting abilities, which allows the surface tension to decrease towards zero at the end of compression and increase towards a high surface tension during re-expansion. In contrast, a time delay between P and R was observed when Tween 20 was assessed. Surface tension adjusting ability was shown only at concentrations below or around the critical micelle concentration (cmc) of Tween 20. Surface tension became unchangeable when concentrations were further increased, suggesting amphipathic molecules were saturated on the interface. The synchronization of transinterface pressure, alveolar radius and surface tension may play an important role in maintaining the pulmonary compliance in vivo. This unique feature, observed at concentrations several orders above the cmc of phospholipids, suggests that the structure of lung surfactant at the air-liquid interface differs from that of Tween 20, a monolayer of free amphipathic molecules.
Authors:
M Liu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  89     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-02-02     Completed Date:  1998-02-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  55-65     Citation Subset:  IM    
Affiliation:
Thoracic Surgery Division, Toronto Hospital, University of Toronto, Ontario, Canada. mingyao.liu@utoronto.ca
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MeSH Terms
Descriptor/Qualifier:
Chemistry, Physical
Physicochemical Phenomena
Pressure
Pulmonary Surfactants / chemistry*
Surface Properties
Surface Tension
Time Factors
Grant Support
ID/Acronym/Agency:
HL-40896/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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