Document Detail


Synchronization of medial temporal lobe and prefrontal rhythms in human decision making.
MedLine Citation:
PMID:  23303925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Optimal decision making requires that we integrate mnemonic information regarding previous decisions with value signals that entail likely rewards and punishments. The fact that memory and value signals appear to be coded by segregated brain regions, the hippocampus in the case of memory and sectors of prefrontal cortex in the case of value, raises the question as to how they are integrated during human decision making. Using magnetoencephalography to study healthy human participants, we show increased theta oscillations over frontal and temporal sensors during nonspatial decisions based on memories from previous trials. Using source reconstruction we found that the medial temporal lobe (MTL), in a location compatible with the anterior hippocampus, and the anterior cingulate cortex in the medial wall of the frontal lobe are the source of this increased theta power. Moreover, we observed a correlation between theta power in the MTL source and behavioral performance in decision making, supporting a role for MTL theta oscillations in decision-making performance. These MTL theta oscillations were synchronized with several prefrontal sources, including lateral superior frontal gyrus, dorsal anterior cingulate gyrus, and medial frontopolar cortex. There was no relationship between the strength of synchronization and the expected value of choices. Our results indicate a mnemonic guidance of human decision making, beyond anticipation of expected reward, is supported by hippocampal-prefrontal theta synchronization.
Authors:
Marc Guitart-Masip; Gareth R Barnes; Aidan Horner; Markus Bauer; Raymond J Dolan; Emrah Duzel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-10     Completed Date:  2013-03-04     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  442-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticipation, Psychological
Behavior / physiology
Cortical Synchronization*
Decision Making / physiology*
Female
Hippocampus / physiology
Humans
Learning / physiology
Magnetoencephalography
Male
Memory / physiology
Prefrontal Cortex / physiology*
Psychomotor Performance / physiology
Reinforcement (Psychology)
Reward
Temporal Lobe / physiology*
Theta Rhythm / physiology
Young Adult
Grant Support
ID/Acronym/Agency:
078865//Wellcome Trust; 078865/Z/12/Z//Wellcome Trust; 091593//Wellcome Trust; 091593/Z/10/Z//Wellcome Trust; 098362//Wellcome Trust
Chemical
Reg. No./Substance:
E78ZFF4KQ0/Reward
Comments/Corrections

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