Document Detail


Synchronization among mechanisms of renal autoregulation is reduced in hypertensive rats.
MedLine Citation:
PMID:  17728377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We searched for synchronization among autoregulation mechanisms using wavelet transforms applied to tubular pressure recordings in nephron pairs from the surface of rat kidneys. Nephrons have two oscillatory modes in the regulation of their pressures and flows: a faster (100-200 mHz) myogenic mode, and a slower (20-40 mHz) oscillation in tubuloglomerular feedback (TGF). These mechanisms interact; the TGF mode modulates both the amplitude and the frequency of the myogenic mode. Nephrons also communicate with each other using vascular signals triggered by membrane events in arteriolar smooth muscle cells. In addition, the TGF oscillation changes in hypertension to an irregular fluctuation with characteristics of deterministic chaos. The analysis shows that, within single nephrons of normotensive rats, the myogenic mode and TGF are synchronized at discrete frequency ratios, with 5:1 most common. There is no distinct synchronization ratio in spontaneously hypertensive rats (SHR). In normotensive rats, full synchronization of both TGF and myogenic modes is the most probable state for pairs of nephrons originating in a common cortical radial artery. For SHR, full synchronization is less probable; most common in SHR is a state of partial synchronization with entrainment between neighboring nephrons for only one of the modes. Modulation of the myogenic mode by the TGF mode is much stronger in hypertensive than in normotensive rats. Synchronization among nephrons forms the basis for an integrated reaction to blood pressure fluctuations. Reduced synchronization in SHR suggests that the effectiveness of the coordinated response is impaired in hypertension.
Authors:
Olga V Sosnovtseva; Alexey N Pavlov; Erik Mosekilde; Kay-Pong Yip; Niels-Henrik Holstein-Rathlou; Donald J Marsh
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-08-29
Journal Detail:
Title:  American journal of physiology. Renal physiology     Volume:  293     ISSN:  1931-857X     ISO Abbreviation:  Am. J. Physiol. Renal Physiol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-31     Completed Date:  2007-12-18     Revised Date:  2011-04-28    
Medline Journal Info:
Nlm Unique ID:  100901990     Medline TA:  Am J Physiol Renal Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  F1545-55     Citation Subset:  IM    
Affiliation:
Department of Physics, The Technical University of Denmark, Kongens Lyngby, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterioles / physiopathology
Feedback, Physiological
Homeostasis*
Hypertension / physiopathology*
Kidney / physiopathology*
Kidney Glomerulus / physiopathology
Kidney Tubules / physiopathology
Male
Models, Biological
Muscle, Smooth, Vascular / physiopathology
Nephrons / blood supply,  physiopathology
Oscillometry
Rats
Rats, Inbred SHR*
Rats, Sprague-Dawley
Time Factors
Grant Support
ID/Acronym/Agency:
DK15968/DK/NIDDK NIH HHS; EB003508/EB/NIBIB NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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