Document Detail

Synchronicity of systolic deformation in healthy pediatric and young adult subjects: a two-dimensional strain echocardiography study.
MedLine Citation:
PMID:  21984551     Owner:  NLM     Status:  MEDLINE    
Two-dimensional speckle tracking echocardiography (2DSTE) offers valuable information in the echocardiographic assessment of ventricular myocardial function. It enables the quantification and timing of systolic ventricular myocardial deformation. In addition, 2DSTE can be used to identify mechanical dyssynchrony, which is an important parameter in predicting the response to cardiac resynchronization therapy for heart failure. Detailed knowledge of normal timing of systolic deformation and its degree of synchronicity in children is lacking. We aimed to establish the normal timing of left ventricular myocardial systolic deformation using 2DSTE in a large cohort of healthy children and young adults. Transthoracic echocardiograms were acquired in 195 healthy subjects (139 children and 56 young adult <40 yr of age) and were retrospectively analyzed. Time to peak systolic longitudinal, circumferential, and radial strain was determined by means of speckle tracking. Strong, statistically significant relations between age as well as various anthropometric variables (e.g., heart rate) and timing of systolic deformation (P < 0.0001) were present. The extent of dyssynchronous deformation increased with age. This is the first report that establishes reference values per cardiac segment for time to peak systolic myocardial strain values in all three directions assessed with 2DSTE in a large pediatric and young adult cohort. We emphasize the need for using age-specific reference values as well as heart rate correction for the adequate interpretation of 2DSTE measurements.
Karen A Marcus; Jan Janousek; Marlieke E Barends; Gert Weijers; Chris L de Korte; Livia Kapusta
Publication Detail:
Type:  Journal Article     Date:  2011-10-07
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  302     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-27     Completed Date:  2012-02-14     Revised Date:  2012-05-23    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H196-205     Citation Subset:  IM    
Children's Heart Centre, Radboud University Nijmegen Medical Centre, The Netherlands.
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MeSH Terms
Age Factors
Aging / physiology*
Analysis of Variance
Child, Preschool
Echocardiography, Doppler*
Echocardiography, Doppler, Pulsed
Heart Rate*
Heart Ventricles / ultrasonography*
Infant, Newborn
Predictive Value of Tests
Reference Values
Retrospective Studies
Time Factors
Ventricular Function, Left*
Young Adult

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