Document Detail


Synaptic remodeling in the rat arcuate nucleus during the estrous cycle.
MedLine Citation:
PMID:  2601838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adult female rats showing regular vaginal cycles were studied in order to determine the number of axosomatic synapses in thin sections of the arcuate nucleus. The number of synapses per length of perikaryal membrane was significantly decreased in estrus, compared to other days of the estrous cycle (P less than 0.05). The reduction in the number of synapses in estrus was accompanied by a decrease in the percentage of the average length of perikaryal membrane covered by presynaptic terminals and by an increase in the percentage of membrane in close apposition of glial processes. Since the average perikaryal perimeter was not significantly changed during the estrous cycle, these results indicate a net decrease in the number of arcuate nucleus axosomatic synapses between proestrus and estrus, with a reinnervation of arcuate neurons between estrus and metestrus. These results suggest that there is a physiological synaptic turnover in the arcuate nucleus of the rat during the estrous cycle.
Authors:
G Olmos; F Naftolin; J Perez; P A Tranque; L M Garcia-Segura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience     Volume:  32     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  1989  
Date Detail:
Created Date:  1990-02-01     Completed Date:  1990-02-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  663-7     Citation Subset:  IM    
Affiliation:
Instituto Cajal, C.S.I.C., Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arcuate Nucleus / physiology*,  ultrastructure
Cell Count
Estrus*
Female
Neuronal Plasticity*
Rats
Rats, Inbred Strains
Synapses / physiology*,  ultrastructure
Grant Support
ID/Acronym/Agency:
HD-13587/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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