| Synaptic integration of NMDA and non-NMDA receptors in large neuronal network models solved by means of differential equations. | |
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MedLine Citation:
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PMID: 8136409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alpha functions are commonly used to describe different receptor channel kinetics (non-NMDA, GABAA and GABAB). In this paper we show that they may be represented as solutions to simple ordinary differential equations. This alternative method is compared with the commonly used direct summation of the alpha function conductances in a high-level neuronal circuit model. A parametric study shows that the differential equation method greatly speeds up the previous summation method. The forward Euler method used to solve this differential equation is shown to be accurate for this type of simulation. The modelling of NMDA receptor channel kinetics is also discussed. |
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Authors:
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C Bernard; Y C Ge; E Stockley; J B Willis; H V Wheal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological cybernetics Volume: 70 ISSN: 0340-1200 ISO Abbreviation: Biol Cybern Publication Date: 1994 |
Date Detail:
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Created Date: 1994-04-25 Completed Date: 1994-04-25 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 7502533 Medline TA: Biol Cybern Country: GERMANY |
Other Details:
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Languages: eng Pagination: 267-73 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, Southampton University, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / physiology Kinetics Mathematics Membrane Potentials Models, Neurological* Nerve Net / physiology* Neurons / physiology* Receptors, GABA-A / physiology* Receptors, GABA-B / physiology* Receptors, N-Methyl-D-Aspartate / physiology* Synapses / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Receptors, GABA-A; 0/Receptors, GABA-B; 0/Receptors, N-Methyl-D-Aspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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