| Synaptic drive at developing synapses: transient upregulation of kainate receptors. | |
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MedLine Citation:
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PMID: 20518018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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At the onset of a period of intense synaptic refinement initiated by synchronized eye opening (EO), rapid changes in postsynaptic NMDA receptor and AMPA receptor currents (NMDARcs and AMPARcs) occur within the superficial visual layers of the rodent superior colliculus (sSC; Lu and Constantine-Paton [2004]: Neuron 43:237-249). Subsequently, evoked non-NMDARc amplitudes increase, but by 2 weeks after EO (AEO) they decrease significantly. Here, using whole-cell patch-clamp recording, we demonstrate that small, slowly desensitizing excitatory kainate receptor currents (KARcs) are responsible for the rise and subsequent fall in non-NMDARcs. The increase in KAR transmission parallels inhibitory GABA(A) responses that plateau at 7 days AEO. By 2 weeks AEO, KARcs are gone. AMPARcs remain unchanged during the appearance and disappearance of the KARcs, despite increases in sSC neuropil activity and continued refinement of inputs to individual sSC neurons. We suggest that in the interval of heightened activity, before SC inhibition matures, many AMPARcs desensitize and are relatively ineffective at relieving the Mg(2+) block on NMDARs. This transient appearance of slowly desensitizing, long-duration KARcs may provide increased membrane depolarization necessary for NMDAR function and continuation of synaptic refinement. |
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Authors:
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Brigitte van Zundert; Jiang-Ping Zhao; Martha Constantine-Paton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental neurobiology Volume: 70 ISSN: 1932-846X ISO Abbreviation: Dev Neurobiol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-25 Completed Date: 2010-12-10 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 101300215 Medline TA: Dev Neurobiol Country: United States |
Other Details:
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Languages: eng Pagination: 737-50 Citation Subset: IM |
Affiliation:
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McGovern Institute for Brain Research and Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. bvanzundert@unab.cl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Membrane Potentials / physiology Neurons / metabolism Patch-Clamp Techniques Rats Rats, Sprague-Dawley Receptors, AMPA / metabolism Receptors, Kainic Acid / metabolism* Receptors, N-Methyl-D-Aspartate / metabolism Superior Colliculi / growth & development*, metabolism* Synapses / physiology* Up-Regulation |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY014074-17/EY/NEI NIH HHS; R01 EY014074-18/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, AMPA; 0/Receptors, Kainic Acid; 0/Receptors, N-Methyl-D-Aspartate |
| Comments/Corrections | |
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