Document Detail


Synaptic contacts between an identified type of ON cone bipolar cell and ganglion cells in the mouse retina.
MedLine Citation:
PMID:  15813935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We surveyed the potential contacts between an identified type of bipolar cell and retinal ganglion cells in the mouse. By crossing two existing mouse strains (line 357 and line GFP-M), we created a double transgenic strain in which GFP is expressed by all members of a single type of ON cone bipolar cell and a sparse, mixed population of retinal ganglion cells. The GFP-expressing bipolar cells appear to be those termed CB4a of Pignatelli & Strettoi [(2004) J. Comp. Neurol., 476, 254-266] and type 7 of Ghosh et al. [(2004) J. Comp. Neurol., 469, 70-82 and J. Comp. Neurol., 476, 202-203]. The labelled ganglion cells include examples of most or all types of ganglion cells present in the mouse. By studying the juxtaposition of their processes in three dimensions, we could learn which ganglion cell types are potential synaptic targets of the line 357 bipolar cell. Of 12 ganglion cell types observed, 10 types could be definitively ruled out as major synaptic targets of the line 357 bipolar cells. One type of monostratified ganglion cell and one bistratified cell tightly cofasciculate with axon terminals of the line 357 bipolar cells. Double labelling for kinesin II demonstrates colocalization of bipolar cell ribbons at the sites of contact between these two types of ganglion cell and the line 357 bipolar cells.
Authors:
Bin Lin; Richard H Masland
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  21     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-04-07     Completed Date:  2005-05-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  1257-70     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, 50 Blossom Street, Wellman 429, Boston, MA 02114, USA. blin@helix.mgh.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Fluorescent Dyes / metabolism
Green Fluorescent Proteins / biosynthesis,  genetics
Immunohistochemistry / methods
Mice
Mice, Transgenic
Microscopy, Confocal / methods
Neurons / classification,  cytology*,  metabolism
Organic Chemicals
Presynaptic Terminals / metabolism
Retina / cytology*
Retinal Cone Photoreceptor Cells*
Retinal Ganglion Cells / classification,  cytology*
Synapses / classification*,  physiology*
Chemical
Reg. No./Substance:
0/Alexa594; 0/Fluorescent Dyes; 0/Organic Chemicals; 147336-22-9/Green Fluorescent Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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