Document Detail


Synaptic changes in the brain of subjects with schizophrenia.
MedLine Citation:
PMID:  21382468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical, epidemiological, neuroimaging and postmortem data all suggest schizophrenia is a neurodevelopmental disorder, and that synaptic disturbances might play a critical role in developing the disease. In 1982, Feinberg proposed that the schizophrenia might arise as a result of abnormal synaptic pruning. His hypothesis has survived 40years of accumulated data, and we review the critical findings related to synaptic dysfunction of schizophrenia. While it is clear that synaptic disturbances are integral and important for understanding the pathophysiology of schizophrenia, it has also become obvious that synaptic disturbances cannot be studied and understood as an independent disease hallmark, but only as a part of a complex network of homeostatic events. Development, glial-neural interaction, changes in energy homeostasis, diverse genetic predisposition, neuroimmune processes and environmental influences all can tip the delicate homeostatic balance of the synaptic morphology and connectivity in a uniquely individual fashion, thus contributing to the emergence of the various symptoms of this devastating disorder. Finally, we argue that based on a predominant change in gene expression pattern we can broadly sub-stratify schizophrenia into "synaptic" "oligodendroglial", "metabolic" and "inflammatory" subclasses.
Authors:
Gábor Faludi; Károly Mirnics
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-03-05
Journal Detail:
Title:  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience     Volume:  29     ISSN:  1873-474X     ISO Abbreviation:  Int. J. Dev. Neurosci.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-11     Completed Date:  2011-07-20     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  8401784     Medline TA:  Int J Dev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  305-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 ISDN. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Schizophrenia / pathology*,  physiopathology*
Synapses / pathology*,  physiology*,  ultrastructure
Grant Support
ID/Acronym/Agency:
R01 MH067234/MH/NIMH NIH HHS; R01 MH067234-09/MH/NIMH NIH HHS; R01 MH079299/MH/NIMH NIH HHS; R01 MH079299-05/MH/NIMH NIH HHS; R01MH067234/MH/NIMH NIH HHS; R01MH079299/MH/NIMH NIH HHS
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