| Synaptic Network Activity Induces Neuronal Differentiation of Adult Hippocampal Precursor Cells through BDNF Signaling. | |
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MedLine Citation:
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PMID: 20582276 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Adult hippocampal neurogenesis is regulated by activity. But how do neural precursor cells in the hippocampus respond to surrounding network activity and translate increased neural activity into a developmental program? Here we show that long-term potentiation (LTP)-like synaptic activity within a cellular network of mature hippocampal neurons promotes neuronal differentiation of newly generated cells. In co-cultures of precursor cells with primary hippocampal neurons, LTP-like synaptic plasticity induced by addition of glycine in Mg(2+)-free media for 5 min, produced synchronous network activity and subsequently increased synaptic strength between neurons. Furthermore, this synchronous network activity led to a significant increase in neuronal differentiation from the co-cultured neural precursor cells. When applied directly to precursor cells, glycine- and Mg(2+)-free solution did not induce neuronal differentiation. Synaptic plasticity-induced neuronal differentiation of precursor cells was observed in the presence of GABAergic neurotransmission blockers but was dependent on NMDA-mediated Ca(2+) influx. Most importantly, neuronal differentiation required the release of brain-derived neurotrophic factor (BDNF) from the underlying substrate hippocampal neurons as well as TrkB receptor phosphorylation in precursor cells. This suggests that activity-dependent stem cell differentiation within the hippocampal network is mediated via synaptically evoked BDNF signaling. |
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Authors:
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Harish Babu; Gerardo Ramirez-Rodriguez; Klaus Fabel; Josef Bischofberger; Gerd Kempermann |
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Publication Detail:
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Type: Journal Article Date: 2009-09-30 |
Journal Detail:
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Title: Frontiers in neuroscience Volume: 3 ISSN: 1662-453X ISO Abbreviation: Front Neurosci Publication Date: 2009 |
Date Detail:
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Created Date: 2010-06-28 Completed Date: 2011-07-14 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 101478481 Medline TA: Front Neurosci Country: Switzerland |
Other Details:
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Languages: eng Pagination: 49 Citation Subset: - |
Affiliation:
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Max Delbrück Center for Molecular Medicine Berlin-Buch Berlin, Germany. |
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