Document Detail


Synaptic Network Activity Induces Neuronal Differentiation of Adult Hippocampal Precursor Cells through BDNF Signaling.
MedLine Citation:
PMID:  20582276     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Adult hippocampal neurogenesis is regulated by activity. But how do neural precursor cells in the hippocampus respond to surrounding network activity and translate increased neural activity into a developmental program? Here we show that long-term potentiation (LTP)-like synaptic activity within a cellular network of mature hippocampal neurons promotes neuronal differentiation of newly generated cells. In co-cultures of precursor cells with primary hippocampal neurons, LTP-like synaptic plasticity induced by addition of glycine in Mg(2+)-free media for 5 min, produced synchronous network activity and subsequently increased synaptic strength between neurons. Furthermore, this synchronous network activity led to a significant increase in neuronal differentiation from the co-cultured neural precursor cells. When applied directly to precursor cells, glycine- and Mg(2+)-free solution did not induce neuronal differentiation. Synaptic plasticity-induced neuronal differentiation of precursor cells was observed in the presence of GABAergic neurotransmission blockers but was dependent on NMDA-mediated Ca(2+) influx. Most importantly, neuronal differentiation required the release of brain-derived neurotrophic factor (BDNF) from the underlying substrate hippocampal neurons as well as TrkB receptor phosphorylation in precursor cells. This suggests that activity-dependent stem cell differentiation within the hippocampal network is mediated via synaptically evoked BDNF signaling.
Authors:
Harish Babu; Gerardo Ramirez-Rodriguez; Klaus Fabel; Josef Bischofberger; Gerd Kempermann
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Publication Detail:
Type:  Journal Article     Date:  2009-09-30
Journal Detail:
Title:  Frontiers in neuroscience     Volume:  3     ISSN:  1662-453X     ISO Abbreviation:  Front Neurosci     Publication Date:  2009  
Date Detail:
Created Date:  2010-06-28     Completed Date:  2011-07-14     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101478481     Medline TA:  Front Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  49     Citation Subset:  -    
Affiliation:
Max Delbrück Center for Molecular Medicine Berlin-Buch Berlin, Germany.
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