| Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. | |
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MedLine Citation:
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PMID: 22959887 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Docosahexaenoylethanolamide, the structural analog of the endogenous cannabinoid receptor ligand anandamide, is synthesized from docosahexaenoic acid (DHA) in the brain. Although docosahexaenoylethanolamide binds weakly to cannabinoid receptors, it stimulates neurite growth, synaptogenesis and glutamatergic synaptic activity in developing hippocampal neurons at concentrations of 10-100nM. We have previously proposed the term synaptamide for docosahexaenoylethanolamide to emphasize its potent synaptogenic activity and structural similarity to anandamide. Synaptamide is subjected to hydrolysis by fatty acid amide hydrolase, and can be oxygenated to bioactive metabolites. The brain synaptamide content is dependent on the dietary DHA intake, suggesting an endogenous mechanism whereby diets containing adequate amounts of omega-3 fatty acids improve synaptogenesis in addition to well-recognized anti-inflammatory effects. |
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Authors:
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Hee-Yong Kim; Arthur A Spector |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-4 |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: - ISSN: 1532-2823 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Published by Elsevier Ltd. |
Affiliation:
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Laboratory of Molecular Signaling, DICBR, NIAAA, NIH, Bethesda, MD 20892-9410, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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