Document Detail


Synapsin Ia, synapsin Ib, protein IIIa, and protein IIIb, four related synaptic vesicle-associated phosphoproteins, share regional and cellular localization in rat brain.
MedLine Citation:
PMID:  3138387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The regional and cellular distribution of four synaptic vesicle-associated proteins, synapsins Ia and Ib (Mr 86,000 and 80,000, collectively referred to as synapsin I) and proteins IIIa and IIIb (Mr 74,000 and 55,000, collectively referred to as protein III), has been compared in selected rat brain regions, using both radioimmunoassays and back-phosphorylation assays. Lesions of several neuronal populations in the basal ganglia (corticostriatal fibers, intrinsic striatal neurons, striatonigral fibers, nigrostriatal fibers) induced decreases in the levels of these various proteins that were highly correlated (r = 0.96-0.97). Moreover, the synaptic vesicle-associated phosphoproteins displayed a similar and widespread distribution throughout the CNS. This evidence for colocalization indicates that the majority of, and possibly all, CNS neurons and nerve terminals may contain both forms of synapsin I and both forms of protein III.
Authors:
S I Walaas; M D Browning; P Greengard
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  51     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-10-19     Completed Date:  1988-10-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1214-20     Citation Subset:  IM    
Affiliation:
laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / drug effects
Brain Chemistry*
Cerebral Cortex / physiology
Corpus Striatum / physiology
Kainic Acid / pharmacology
Male
Nerve Tissue Proteins / analysis*,  metabolism
Neuropeptides / analysis*,  metabolism
Phosphoproteins / analysis
Phosphorylation
Radioimmunoassay
Rats
Rats, Inbred Strains
Substantia Nigra / physiology
Synapsins
Synaptic Vesicles / analysis*
Tissue Distribution
Grant Support
ID/Acronym/Agency:
AA 06944/AA/NIAAA NIH HHS; MH 39327/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Neuropeptides; 0/Phosphoproteins; 0/Synapsins; 487-79-6/Kainic Acid

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