Document Detail

Synacthen Depot for the treatment of postdural puncture headache.
MedLine Citation:
PMID:  14725516     Owner:  NLM     Status:  MEDLINE    
We conducted a prospective, randomised, double-blind trial to study the effect of Synacthen Depot in 18 parturients with postdural puncture headache following deliberate or accidental dural puncture. Women were randomly allocated to receive either Synacthen Depot 1 mg (1 ml) or 0.9% saline 1 ml intramuscularly. Using a 10-cm visual analogue scale, severity of headache was measured before and at intervals until 48 h after injection. There was no difference in the severity of headache or requirement for epidural blood patch. We conclude that there is no advantage to the use of Synacthen Depot 1 mg for the treatment of postdural puncture headache.
M W M Rucklidge; S M Yentis; M J Paech
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  59     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-16     Completed Date:  2004-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  138-41     Citation Subset:  AIM; IM    
Magill Department of Anaesthesia, Intensive Care & Pain Management, Chelsea and Westminster Hospital, London SW10 9NH, UK.
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MeSH Terms
Anesthesia, Epidural / adverse effects*
Anesthesia, Obstetrical / adverse effects*
Blood Patch, Epidural
Cosyntropin / therapeutic use*
Delayed-Action Preparations
Double-Blind Method
Dura Mater / injuries*
Headache / drug therapy*,  etiology
Injections, Epidural / adverse effects
Pain Measurement
Prospective Studies
Reg. No./Substance:
0/Delayed-Action Preparations; 16960-16-0/Cosyntropin; 53468-06-7/adrenocorticotropin zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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