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Symptoms and their Relationship to Disability Following Treatment for Lower Extremity Tumours.
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MedLine Citation:
PMID:  18521266     Owner:  NLM     Status:  In-Data-Review    
Purpose. The aims of this study were to describe the symptoms experienced by patients in the first year following treatment for lower extremity sarcoma by limb conservation and to describe the relationship between symptoms and physical disability.Subjects. Eighty consecutive patients treated for primary bone or soft tissue sarcoma (STS) of the lower limb who were treated with limb preservation surgery.Methods. Subjects were evaluated by questionnaire at 6 weeks, and 3, 6, and 12 months post surgery. They identified whether they experienced any of the following symptoms: pain, stiffness, fatigue, weakness, limited range of motion, or swelling.The Toronto Extremity Salvage Score (TESS), a measure of physical disability, was also completed. Frequency of symptoms over time was calculated and change was evaluated using the Cochrane test. The relationship of symptoms to disability was analyzed with regression methods.Results. The mean age was 43.0, SD=20.4 with a gender ratio of 1:1. There were 38 bone tumours and 42 STS.The most frequently reported symptoms were: stiffness 48 (60%), weakness 41 (51%), fatigue 26 (33%), and pain 25 (31%) at 6 weeks. Stiffness and fatigue decreased and plateaued by 3 months. Complaints of weakness and pain continued to decrease over time. At 6 weeks, pain, stiffness, weakness and limited motion predicted disability in both univariate and multivariate analyses. At 12 months, pain, stiffness, fatigue, weakness and limited motion were significant predictors of the TESS in univariate analysis with only pain, stiffness and limited motion significant predictors in the multivariate model.Discussion. Pain, stiffness, fatigue, weakness and limited motion are common symptoms with stiffness and weakness decreasing significantly over time. The symptoms predictive of disability differ between the acute and late phases of recovery.
A M Davis; S Punniyamoorthy; A M Griffin; J S Wunder; R S Bell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sarcoma     Volume:  3     ISSN:  1357-714X     ISO Abbreviation:  Sarcoma     Publication Date:  1999  
Date Detail:
Created Date:  2008-06-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709257     Medline TA:  Sarcoma     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  73-7     Citation Subset:  -    
The University Musculoskeletal Oncology Unit Mount Sinai Hospital and The University of Toronto Toronto Canada.
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Journal Information
Journal ID (nlm-ta): Sarcoma
ISSN: 1357-714X
ISSN: 1369-1643
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright © 1999 Hindawi Publishing Corporation.
open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Print publication date: Month: 9 Year: 1999
Volume: 3 Issue: 2
First Page: 73 Last Page: 77
ID: 2395419
PubMed Id: 18521266
Publisher Item Identifier: S1357714X99000092
DOI: 10.1080/13577149977677

Symptoms and their Relationship to Disability Following Treatment for Lower Extremity Tumours
Aileen M. Davis12
Sajeevan Punniyamoorthy1
Anthony M. Griffin1
Jay S. Wunder1
Robert S. Bell1
1The University Musculoskeletal Oncology UnitMount Sinai Hospital and The University of TorontoTorontoCanada
2Suite 476HMount Sinai Hospital600 University AvenueTorontoM5G 1X5Canada

Article Categories:
  • Research Article

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