Document Detail

Symptoms and signs of an acute myocardial ischemia caused by chemotherapy with Paclitaxel (Taxol) in a patient with metastatic ovarian carcinoma.
MedLine Citation:
PMID:  16354605     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Paclitaxel (Taxol) is an anticancer agent used for the treatment of breast and ovarian cancer. The major side effects are bone marrow suppression, alopecia, polyneuropathy and cardiac toxicity like bradycardia, myocardial infarction, congestive heart failure and cardiac death. SETTING: Intensive care unit (ICU) of a university hospital. PATIENT: We report on a 58-years-old woman with a metastatic ovarian carcinoma who had chest pain, nausea and collapse during their first Taxol infusion. The infusion was stopped and the patient was submitted to the intensive care unit (ICU) to exclude an acute coronary syndrome. RESULTS: The electrocardiography (ECG) showed a third-degree heart block and ST elevation in II, III and avF. In the initial and in the control laboratory investigation values of cardiac enzymes (creatininkinase and Troponine T) remained normal. The control ECG after 30 minutes turned back to normal. After one day the patient was submitted back to a normal ward. CONCLUSION: Symptomatic bradyarrhythmia and clinical sign of an myocardial infarction are rare but important cardiac side effects in patients treated with Taxol. Those patients should be under intensive care unit until patients conditions improve and acute myocardial ischemia has been excluded.
Carsten Schrader; C Keussen; B Bewig; A von Freier; M Lins
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of medical research     Volume:  10     ISSN:  0949-2321     ISO Abbreviation:  Eur. J. Med. Res.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-12-15     Completed Date:  2006-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9517857     Medline TA:  Eur J Med Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  498-501     Citation Subset:  IM    
2nd Department of Internal Medicine, University Hospital of Schleswig-Holstein, Kiel, Chemnitzstrasse 33, D-24116 Kiel, Germany.
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MeSH Terms
Acute Disease
Angina Pectoris / chemically induced
Anticoagulants / therapeutic use
Antineoplastic Agents, Phytogenic / administration & dosage,  adverse effects*
Bradycardia / chemically induced
Carcinoma / drug therapy*,  pathology
Follow-Up Studies
Heparin / therapeutic use
Middle Aged
Myocardial Ischemia / chemically induced*,  physiopathology*
Nausea / chemically induced
Neoplasm Metastasis / drug therapy,  pathology
Neoplasm Staging
Ovarian Neoplasms / drug therapy*,  pathology*
Paclitaxel / administration & dosage,  adverse effects*
Treatment Outcome
Reg. No./Substance:
0/Anticoagulants; 0/Antineoplastic Agents, Phytogenic; 33069-62-4/Paclitaxel; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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