Document Detail


Symptoms and quality of life in obese children and adolescents with non-alcoholic fatty liver disease.
MedLine Citation:
PMID:  19863497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Data on the quality of life (QOL) of children with non-alcoholic fatty liver disease (NAFLD) are needed to estimate the true burden of illness in children with NAFLD.
AIM: To characterize QOL and symptoms of children with NAFLD and to compare QOL in children with NAFLD with that in a sample of healthy children.
METHODS: Quality of life and symptoms were assessed in children with biopsy-proven NAFLD enrolled in the NASH Clinical Research Network. PedsQL scores were compared with scores from healthy children. For children with NAFLD, between-group comparisons were made to test associations of demography, histological severity, symptoms and QOL.
RESULTS: A total of 239 children (mean age 12.6 years) were studied. Children with NAFLD had worse total (72.8 vs. 83.8, P < 0.01), physical (77.2 vs. 87.5, P < 0.01) and psychosocial health (70.4 vs. 81.9, P < 0.01) scores compared with healthy children. QOL scores did not significantly differ by histological severity of NAFLD. Fatigue, trouble sleeping and sadness accounted for almost half of the variance in QOL scores. Impaired QOL was present in 39% of children with NAFLD.
CONCLUSIONS: Children with NAFLD have a decrement in QOL. Symptoms were a major determinant of this impairment. Interventions are needed to restore and optimize QOL in children with NAFLD.
Authors:
K D Kistler; J Molleston; A Unalp; S H Abrams; C Behling; J B Schwimmer;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2009-10-23
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  31     ISSN:  1365-2036     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-18     Completed Date:  2010-05-11     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  396-406     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anthropometry
Child
Fatigue / etiology,  psychology*
Fatty Liver / complications,  psychology*
Female
Humans
Male
Obesity / complications,  psychology*
Prevalence
Quality of Life / psychology*
Questionnaires
Reference Values
Severity of Illness Index
Grant Support
ID/Acronym/Agency:
M01 RR000065-46/RR/NCRR NIH HHS; M01 RR000750-36/RR/NCRR NIH HHS; M01 RR000827-34/RR/NCRR NIH HHS; M01RR000065/RR/NCRR NIH HHS; M01RR000750/RR/NCRR NIH HHS; M01RR000827/RR/NCRR NIH HHS; RR02413101/RR/NCRR NIH HHS; U01 DK061713/DK/NIDDK NIH HHS; U01 DK061713-08/DK/NIDDK NIH HHS; U01 DK061718/DK/NIDDK NIH HHS; U01 DK061718-08/DK/NIDDK NIH HHS; U01 DK061728/DK/NIDDK NIH HHS; U01 DK061728-09/DK/NIDDK NIH HHS; U01 DK061730/DK/NIDDK NIH HHS; U01 DK061730-08/DK/NIDDK NIH HHS; U01 DK061731/DK/NIDDK NIH HHS; U01 DK061731-08/DK/NIDDK NIH HHS; U01 DK061732-08/DK/NIDDK NIH HHS; U01 DK061734/DK/NIDDK NIH HHS; U01 DK061734-08/DK/NIDDK NIH HHS; U01 DK061737/DK/NIDDK NIH HHS; U01 DK061737-08/DK/NIDDK NIH HHS; U01 DK061738/DK/NIDDK NIH HHS; U01 DK061738-08/DK/NIDDK NIH HHS; U01DK061713/DK/NIDDK NIH HHS; U01DK061718/DK/NIDDK NIH HHS; U01DK061728,/DK/NIDDK NIH HHS; U01DK061730/DK/NIDDK NIH HHS; U01DK061731/DK/NIDDK NIH HHS; U01DK061732/DK/NIDDK NIH HHS; U01DK061734/DK/NIDDK NIH HHS; U01DK061737/DK/NIDDK NIH HHS; U01DK061738/DK/NIDDK NIH HHS; UL1 RR024989/RR/NCRR NIH HHS; UL1 RR024989-03/RR/NCRR NIH HHS; UL1RR024989/RR/NCRR NIH HHS; UL1RR02501401/RR/NCRR NIH HHS
Investigator
Investigator/Affiliation:
Carol Hawkins / ; Yao-Chang Liu / ; Margaret Stager / ; Arthur McCullough / ; Srinivasan Dasarathy / ; Ruth Sargent / ; Melissa Coffey / ; Karen Murray / ; Melissa Young / ; Parvathi Mohan / ; Manal Abdelmalek / ; Anna Mae Diehl / ; Marcia Gottfried / ; Cynthia Guy / ; Paul Killenberg / ; Samantha Kwan / ; Yi-Ping Pan / ; Dawn Piercy / ; Melissa Smith / ; Prajakta Bhimalli / ; Naga Chalasani / ; Oscar W Cummings / ; Lydia Lee / ; Linda Ragozzino / ; Raj Vuppalanchi / ; Elizabeth Byam / ; Ann Klipsch / ; Jean Molleston / ; Girish Subbarao / ; Kimberly Pfeifer / ; Ann Scheimann / ; Michael Torbenson / ; Sarah Barlow / ; Jose Derdoy / ; Joyce Hoffmann / ; Debra King / ; Andrea Morris / ; Joan Siegner / ; Susan Stewart / ; Brent A Tetri / ; Judy Thompson / ; Cynthia Behling / ; Lisa Clark / ; Janis Durelle / ; Tarek Hassanein / ; Joel E Lavine / ; Susana Mendoza / ; Jeffrey B Schwimmer / ; Claude Sirlin / ; Tanya Stein / ; Zobeida Palomares / ; Bradley Aouizerat / ; Kiran Bambha / ; Nathan M Bass / ; Linda D Ferrell / ; Danuta Filipowski / ; Raphael Merriman / ; Mark Pabst / ; Monique Rosenthal / ; Philip Rosenthal / ; Tessa Steel / ; Matthew Yeh / ; Sherry Boyett / ; Melissa J Contos / ; Michael Fuchs / ; Amy Jones / ; Velimir A C Luketic / ; Bimalijit Sandhu / ; Arun J Sanyal / ; Carol Sargeant / ; Kimberly Selph / ; Melanie White / ; Kris V Kowdley / ; Jody Mooney / ; James Nelson / ; Sarah Ackermann / ; Cheryl Saunders / ; Vy Trinh / ; Chia Wang / ; Elizabeth M Brunt / ; David Kleiner / ; Gilman D Grave / ; Terry T K Huang / ; Edward Doo / ; James Everhart / ; Jay Hoofnagle / ; Patricia R Robuck / ; Leonard Seeff / ; Patricia Belt / ; Frederick L Brancati / ; Jeanne M Clark / ; Ryan Colvin / ; Michele Donithan / ; Mika Green / ; Rosemary Hollick / ; Milana Isaacson / ; Wana Kim / ; Alison Lydecker / ; Pamela Mann / ; Laura Miriel / ; Alice Sternberg / ; James Tonascia / ; Aynur Unalp-Arida / ; Mark Van Natta / ; Laura Wilson / ; Katherine Yates /
Comments/Corrections

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