Document Detail

Symptoms and lung function in health care personnel exposed to glutaraldehyde.
MedLine Citation:
PMID:  12541275     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Glutaraldehyde is widely used as a disinfectant for endoscopic equipment. The aim of this study was to investigate work practices and glutaraldehyde exposure in relation to symptoms and lung function. METHODS: A questionnaire was administered to 76 nurses. Exposed nurses (n = 38) also completed lung function tests and visual analogue scales before and after a work session in which glutaraldehyde exposure occurred. Disinfection activities were timed and counted, personal exposures established, and control measures documented. RESULTS: Exposure values above the exposure limit (0.10 ppm) were found for all exposure control methods except for the enclosed washing machine. Skin symptoms were 3.6 times more likely to be reported by exposed workers. None of the other symptoms were significantly associated with glutaraldehyde exposure. There were significant cross-shift reductions in FVC and FEV(1) in the exposed group. No evidence of a dose-response relationship for symptoms or lung function was found. CONCLUSIONS: Further exposure controls for both glutaraldehyde and gloves are required to improve skin care in glutaraldehyde exposed nurses. Exposure monitoring methods also need review.
Andrew Waters; Jeremy Beach; Michael Abramson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of industrial medicine     Volume:  43     ISSN:  0271-3586     ISO Abbreviation:  Am. J. Ind. Med.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-23     Completed Date:  2003-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8101110     Medline TA:  Am J Ind Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  196-203     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.
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MeSH Terms
Dermatitis, Occupational / etiology*
Disinfectants / adverse effects*
Forced Expiratory Volume / drug effects
Glutaral / adverse effects*
Logistic Models
Occupational Exposure / adverse effects*,  analysis
Odds Ratio
Pain Measurement
Respiratory Function Tests
Reg. No./Substance:
0/Disinfectants; 111-30-8/Glutaral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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