Document Detail

Symptoms and immunologic markers among vulcanization workers in rubber industries in southern Sweden.
MedLine Citation:
PMID:  17717619     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this study was to estimate the risk of symptoms and the possible derangement of levels of immunologic markers for contemporary Swedish rubber workers. Furthermore, the relation between exposure and these biomarkers of response was examined using urinary levels of 2-thiothiazolidine-4-carboxylic acid (TTCA), which reflect the exposure. METHODS: Included in the study were 166 exposed workers and 117 controls. Medical and occupational histories were obtained in structured interviews. Symptoms were recorded, and immunologic markers were analyzed in blood. Urinary levels of TTCA were determined by liquid chromatography tandem mass spectrometry. RESULTS: Compared with the controls, the exposed workers had increased risks of eye symptoms [odds ratio (OR) 3.0], nose bleeds (OR 4.0), burning and dry throat (OR 3.0), hoarseness (OR 2.4), severe dry cough (OR 3.8), nausea (OR 4.3), and headache (OR 2.5). When the exposed workers were divided into three groups according to the TTCA levels, the highest risks were observed among the exposed workers with intermediate TTCA levels. Furthermore, the exposed workers in all of the TTCA subgroups had elevated concentrations of total immunoglobulin G when compared with the controls. Elevated concentrations of leukocytes, neutrophils, and eosinophils were observed in the group with high TTCA levels. CONCLUSIONS: This work shows an increased risk of several symptoms and elevated levels of some immunologic markers among exposed workers in Swedish rubber industries. In addition, relationships between urinary levels of TTCA and some biomarkers of response were reported.
Lena S Jönsson; Karin Broberg; Anna Axmon; Bo Ag Jönsson; Margareta Littorin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  33     ISSN:  0355-3140     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-24     Completed Date:  2007-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  Finland    
Other Details:
Languages:  eng     Pagination:  272-9     Citation Subset:  IM    
Division of Occupational and Environmental Medicine, University Hospital, SE-221 85 Lund, Sweden.
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MeSH Terms
Air Pollutants, Occupational / adverse effects,  immunology*
Biological Markers / analysis*,  urine
Dose-Response Relationship, Immunologic
Interviews as Topic
Middle Aged
Occupational Exposure / adverse effects*,  analysis
Sulfur / adverse effects,  immunology*,  pharmacology
Thiazolidines / analysis,  urine
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Biological Markers; 0/Thiazolidines; 20933-67-9/2-thioxo-4-thiazolidinecarboxylic acid; 7704-34-9/Sulfur; 9006-04-6/Rubber

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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