| Symptoms, haemodynamics, and exercise capacity during long term treatment of chronic heart failure. Experience with pirbuterol. | |
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MedLine Citation:
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PMID: 6137226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An open study of long term treatment with an oral beta 2 agonist (pirbuterol 20 mg three times daily) was undertaken in 63 patients with severe chronic heart failure. During three months of treatment 20 (32%) patients died, of whom 16 were taking the drug at the time of death. Mortality was related to initial functional class (New York Heart Association classification: 23% in grade III and 75% in grade IV). Concomitant treatment with digoxin did not affect mortality. The drug was well tolerated by most patients but unwanted side effects necessitated withdrawal of the drug in six (10%). Thirty-five patients were continuing to take the drug after three months, of whom 22 reported symptomatic improvement and only four deterioration. There was a relation between symptomatic improvement and increase in exercise capacity. At initial haemodynamic assessment a single dose of pirbuterol increased the cardiac index by 34% and the stroke index by 21%. Left ventricular filling pressure fell by 23% and systemic vascular resistance by 22%. Haemodynamic reassessment after three months of continuous treatment in 29 patients showed maintained improvement in the group as a whole, although individual variation was considerable. There was no apparent relation between haemodynamic improvement and improvement in exercise duration and symptoms. Severe heart failure has a poor prognosis. Identification of those patients who may derive benefit from treatment with a particular drug is not yet possible. |
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Authors:
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J R Dawson; R Canepa-Anson; P Kuan; S R Reuben; P A Poole-Wilson; G C Sutton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British heart journal Volume: 50 ISSN: 0007-0769 ISO Abbreviation: Br Heart J Publication Date: 1983 Sep |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370634 Medline TA: Br Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 282-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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adverse effects,
therapeutic use* Adult Aged Cardiotonic Agents / adverse effects, therapeutic use* Ethanolamines / adverse effects, therapeutic use* Female Heart Failure / drug therapy*, physiopathology Hemodynamics / drug effects Humans Male Middle Aged Physical Exertion Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Cardiotonic Agents; 0/Ethanolamines; 38677-81-5/pirbuterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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