Document Detail

Symptoms and differential diagnosis of patients fearing mercury toxicity from amalgam fillings.
MedLine Citation:
PMID:  9456068     Owner:  NLM     Status:  MEDLINE    
Clinical signs, somatic symptoms reported by patients, and mercury excretion in urine were studied for 348 patients selected by odontologists or internists as amalgam-free referents, or as subjects with unexplained clinical findings or who were self-selected due to their fear of mercury intoxication from their amalgam fillings. Sixty patients were excluded because other explanations could be given for their complaints. The age distribution was bimodal, with peaks between 30 and 35 years and between 45 and 50 years. Mercury was determined in a morning urine sample and 30 minutes after the injection of 300 mg of 2,3 dimercapto-1-propane sulfonic acid (DMPS), a mercury-chelating agent. The patients were followed for 1-3 years. Among the patients there were 26 who had had their amalgam fillings removed and who, at the time of the follow-up, were subjectively cured. When the patients were classified according to the excretion of mercury after the DMPS challenge, those who belonged to the upper quartile had an odds ratio of 7.2 (95% confidence interval 3.1-15.2) for becoming cured after amalgam removal. The symptoms of the cured patients had been predominantly mental. No consistent clinical picture could, however, be found among the other patients, as various types of mental and physical distress were reported.
S Stenman; L Grans
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  23 Suppl 3     ISSN:  0355-3140     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  1997  
Date Detail:
Created Date:  1998-03-26     Completed Date:  1998-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  59-63     Citation Subset:  IM    
University of Helsinki, Department of Medicine, Finland.
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MeSH Terms
Analysis of Variance
Chelating Agents / administration & dosage,  diagnostic use
Confidence Intervals
Dental Amalgam / adverse effects*
Diagnosis, Differential
Follow-Up Studies
Injections, Intravenous
Mercury / urine*
Mercury Poisoning / diagnosis*,  etiology,  therapy,  urine
Middle Aged
Odds Ratio
Unithiol / administration & dosage,  diagnostic use
Reg. No./Substance:
0/Chelating Agents; 4076-02-2/Unithiol; 7439-97-6/Mercury; 8049-85-2/Dental Amalgam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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