Document Detail

Symptoms and clinical relevance: A dilemma for clinical trials on prevention of venous thromboembolism.
MedLine Citation:
PMID:  23348892     Owner:  NLM     Status:  Publisher    
The outcomes of thromboprophylactic trials have been debated for decades. Recently, the 9 th edition of the American College of Chest Physicians (ACCP) evidence-based clinical practice guidelines based their strong recommendations only on patient-important outcomes. Practically, symptoms were considered the crucial element. Consequently, studies that primarily aimed at reducing venographic thrombi were considered less pertinent than studies that focused on symptomatic thrombosis. In the present viewpoint, we challenge the argument that "symptomatic" and "clinically relevant" are interchangeable. In particular, the case is made that asymptomatic events may be clinically relevant and that asymptomatic venographically detected thrombosis is a clinically relevant surrogate outcome for fatal pulmonary embolism.
H Bounameaux; G Agnelli
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  109     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Prof. H. Bounameaux, Division of Angiology and Hemostasis, University Hospitals of Geneva (HUG) and Faculty of Medicine, CH-1211 Geneva 14, Switzerland, Tel.: +41 22 3795901, Fax: +41 22 3795002, E-mail :
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