| Symptoms and clinical relevance: A dilemma for clinical trials on prevention of venous thromboembolism. | |
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MedLine Citation:
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PMID: 23348892 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The outcomes of thromboprophylactic trials have been debated for decades. Recently, the 9 th edition of the American College of Chest Physicians (ACCP) evidence-based clinical practice guidelines based their strong recommendations only on patient-important outcomes. Practically, symptoms were considered the crucial element. Consequently, studies that primarily aimed at reducing venographic thrombi were considered less pertinent than studies that focused on symptomatic thrombosis. In the present viewpoint, we challenge the argument that "symptomatic" and "clinically relevant" are interchangeable. In particular, the case is made that asymptomatic events may be clinically relevant and that asymptomatic venographically detected thrombosis is a clinically relevant surrogate outcome for fatal pulmonary embolism. |
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Authors:
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H Bounameaux; G Agnelli |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-24 |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 109 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Prof. H. Bounameaux, Division of Angiology and Hemostasis, University Hospitals of Geneva (HUG) and Faculty of Medicine, CH-1211 Geneva 14, Switzerland, Tel.: +41 22 3795901, Fax: +41 22 3795002, E-mail : henri.bounameaux@unige.ch. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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