Document Detail

Symptoms of autonomic failure in Parkinson's disease: prevalence and impact on daily life.
MedLine Citation:
PMID:  15834763     Owner:  NLM     Status:  MEDLINE    
Frequency and clinical importance of autonomic failure in idiopathic Parkinson's disease (PD) are discussed controversially. 141 patients with PD and 50 healthy age-matched control subjects were interviewed for symptoms of autonomic failure and their influence on daily life using a questionnaire. In PD patients, the prevalence of orthostatic dizziness, bladder dysfunction, erectile dysfunction and hyperhidrosis was significantly higher compared with controls. About 50% of PD patients rated the impact of the symptoms of autonomic failure on their daily lives as "a lot" or "very much" due to orthostatic dizziness, bladder dysfunction and constipation, which were more statistically significant than in age-matched controls. Prevalence and number of autonomic symptoms were not correlated with duration and severity of PD. In 32% of patients, impaired cardiovascular regulation was found by standardized cardiovascular function tests. If testing showed abnormal findings, orthostatic dizziness, bladder dysfunction, constipation and erectile dysfunction were significantly more frequent than in patients with normal regulation, but the impact on daily life due to these symptoms differed significantly only for bladder dysfunction between groups. It is concluded that autonomic failure is a clinically relevant, pervasive problem in PD and compromise patients' daily life activities in all stages of the disease. This underlines the necessity to adequately search for and treat these non-dopaminergic symptoms during the whole course of the disease.
Christiane Magerkurth; Rita Schnitzer; Stefan Braune
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  15     ISSN:  0959-9851     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-18     Completed Date:  2005-07-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  76-82     Citation Subset:  IM    
Dept. of Neurology, University of Freiburg, Freiburg, Germany.
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MeSH Terms
Activities of Daily Living*
Age of Onset
Aged, 80 and over
Antiparkinson Agents / adverse effects,  therapeutic use
Autonomic Nervous System Diseases / epidemiology,  etiology*,  physiopathology*
Heart Function Tests
Hemodynamics / physiology
Hypotension, Orthostatic / etiology,  physiopathology
Middle Aged
Parkinson Disease / complications*,  epidemiology,  physiopathology*
Posture / physiology
Reg. No./Substance:
0/Antiparkinson Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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