Document Detail

Symptomatology and growth in infants with cow's milk protein intolerance using two different whey-protein hydrolysate based formulas in a Primary Health Care setting.
MedLine Citation:
PMID:  8647062     Owner:  NLM     Status:  MEDLINE    
Both growth and the course of allergic symptoms were evaluated in 79 infants with cow's milk protein intolerance, aged three months or younger, diagnosed by standard elimination/provocation and treated with a whey-hydrolysate based infant formula: Nutrilon Pept or Pepti Junior. The efficacy of both products, in terms of symptomatology and growth, was compared with each other. The products differ in fat source (Pepti Junior 50% of its fat as MCT, Nutrilon Pepti normal LCT fat blend) and the presence of lactose (Pepti Junior: lactose free; Nutrilon Pepti: 40% of its carbohydrate as lactose). The study was part of a large project that aimed at standardising the approach towards cow's milk protein intolerance in Baby Health Clinics. Nearly 50 Baby Health Clinics participated in this project. In this study, growth and symptomatology (skin, respiratory tract, gastrointestinal tract) were monitored during an intervention period of at least 10 weeks. Infants in both feeding groups showed normal growth, and in at least 80% of the infants an improvement of the overall symptomatology could be seen during the intervention period. Most profound were the decreases in prevalence and severity of eczema and infantile colic. No differences in efficacy were found in this study between the two infant formulas. It was concluded that the exclusive use of either whey hydrolysate based infant formula resulted in an improvement of allergic symptoms and in normal growth in infants diagnosed by elimination/provocation for cow's milk protein intolerance in a Primary Health Care setting.
J J Verwimp; J G Bindels; M Barents; H S Heymans
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  49 Suppl 1     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-07-25     Completed Date:  1996-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S39-48     Citation Subset:  IM    
Nutricia Research, Zoetermeer, The Netherlands.
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MeSH Terms
Growth Disorders / etiology*
Infant Food* / analysis
Milk Hypersensitivity / complications,  diagnosis,  diet therapy*
Milk Proteins / analysis,  therapeutic use*
Nutritive Value
Protein Hydrolysates / analysis,  therapeutic use*
Reg. No./Substance:
0/Milk Proteins; 0/Protein Hydrolysates; 0/whey protein

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