| Symptomatology during hypoxic exposure to flame-retardant chamber atmospheres. | |
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MedLine Citation:
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PMID: 2107616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypoxia was studied in 12 men during 63-h exposures to 17 and 13% O2, with the subjects serving as their own controls by repeating the measurements in 21% O2. All test atmospheres were contaminated with 0.9% CO2 to simulate the condition of living aboard submarines. The mean SaO2's were 97-98% in all conditions of 21% O2, 96% in 17% O2 (n.s.), and 92% in 13% O2 (P less than 0.05). The blood concentrations of 2,3-diphosphoglycerate were elevated in 13 and 17% O2 (P less than 0.05). Seventeen percent O2 did not cause significant symptoms of environmental stress; however, 13% O2 caused symptoms of acute mountain sickness in 5 of 12 men. In the last 7 h of exposure to 17% O2, reduction of the barometric pressure to 576 Torr reduced the ambient PO2 to 98 Torr (similar to the PO2 of 13% O2 at normobaric pressure). This induced symptoms of acute mountain sickness in 3 of 11 men. All symptomatology and physiologic changes were reversed during recovery in 21% O2. Monitoring devices indicated the presence of volatile organic contaminants at a mean concentration of 6.1 ppm in the chamber atmosphere. Combustion tests in the occupied chamber showed that flame propagation was retarded by lowering the O2 concentration from 21 to 13-17%. We conclude that men can live comfortably in a normobaric, flame-retardant atmosphere consisting of 17% O2-0.9% CO2-6.1 ppm volatile organic compounds-balance N2. |
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Authors:
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D R Knight; A Cymerman; J A Devine; R L Burse; C S Fulco; P B Rock; D V Tappan; A A Messier; H Carhart |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Undersea biomedical research Volume: 17 ISSN: 0093-5387 ISO Abbreviation: Undersea Biomed Res Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-04-13 Completed Date: 1990-04-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421514 Medline TA: Undersea Biomed Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 33-44 Citation Subset: IM; S |
Affiliation:
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Naval Submarine Medical Research Laboratory, Naval Submarine Base, Groton, CT 06349-5900. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2,3-Diphosphoglycerate Adult Altitude Sickness / etiology Anoxia / blood, complications* Atmosphere Carbon Dioxide Diphosphoglyceric Acids / blood Fires / prevention & control Flame Retardants / adverse effects* Humans Male Nitrogen Oxygen Respiration Safety |
| Chemical | |
Reg. No./Substance:
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0/Diphosphoglyceric Acids; 0/Flame Retardants; 124-38-9/Carbon Dioxide; 138-81-8/2,3-Diphosphoglycerate; 7727-37-9/Nitrogen; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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