Document Detail

Symptomatic hypoglycemia related to inappropriately high igf-ii serum levels in a patient with desmoplastic small round cell tumor.
MedLine Citation:
PMID:  20592985     Owner:  NLM     Status:  PubMed-not-MEDLINE    
A 45-year old man was diagnosed with desmoplastic small round cell tumor (DSRCT) with involvement of the peritoneum and pelvis. Disease progression was observed despite systemic chemotherapy. Six months after diagnosis, he developed severe hypoglycemia presented with seizures. He received intravenous glucose infusion and hydrocortisone with poor glycemic control, but with seizures resolution. The investigation excluded insulinoma, adrenal, liver and GH deficiencies. Laboratory showed slight rise of IGF-II and significant increase of the ratio IGF-II : IGF-I, which is pathognomonic of non-islet cell tumor hypoglycemia (NICTH). He received the diagnoses of NICTH related to IGF-II inappropriate production by DSRCT. Despite the attempt to control tumor mass and hypoglycemia, the patient died 9 months after diagnosis. NICTH related to inappropriate IGF-II secretion should be investigated in all cancer patients with refractory hypoglycemia whom insulinoma and other metabolic abnormalities were excluded from.
Williams Fernandes Barra; Gilberto Castro; Ana Oliveira Hoff; Sheila A C Siqueira; Paulo M Hoff
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Publication Detail:
Type:  Journal Article     Date:  2010-06-02
Journal Detail:
Title:  Case reports in medicine     Volume:  2010     ISSN:  1687-9635     ISO Abbreviation:  Case Rep Med     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-01     Completed Date:  2011-07-14     Revised Date:  2013-02-21    
Medline Journal Info:
Nlm Unique ID:  101512910     Medline TA:  Case Rep Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  684045     Citation Subset:  -    
Departamento de Oncologia Clínica, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
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