Document Detail

Symptomatic epidural compression in infants with neuroblastoma: a single-center experience with 5 cases.
MedLine Citation:
PMID:  23612376     Owner:  NLM     Status:  In-Data-Review    
Infants affected by neuroblastoma with symptomatic epidural compression require early diagnosis and appropriate treatment to avoid severe late complications. However, no established guidelines are available regarding the optimal treatment of these patients. We describe 5 such infants. The interval between the onset of symptoms and tumor diagnosis was 3 to 8 days in 4/5 cases. None developed paraplegia before or after treatment. Treatment for epidural compression included first-line laminoplasty followed by chemotherapy in 3 patients, and chemotherapy first in the remaining 2. To date, all are alive and none have developed severe complications after a follow-up of 9 to 39 months (median, 20).
Maria Capasso; Giuseppe Cinalli; Anna Nastro; Maria Giuliano; Maria E Errico; Umberto Caccioppoli; Rossella Turco; Serena Ruotolo; Simona Vetrella; Bruno De Bernardi; Eugenio Rossi; Lucia Quaglietta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  35     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  260-6     Citation Subset:  IM    
*Department of Oncology †Department of Neurosurgery ‡Service of Neuro-radiology §Service of Pathology ∥Division of Oncologic Surgery #Service of Diagnostic Imaging, Santobono-Pausilipon Children's Hospital, Naples ¶Department of Hematology and Oncology, Giannina Gaslini Children's Hospital, Genoa, Italy.
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