Document Detail

Symptomatic dermatographism: current concepts in clinical practice with an emphasis on the pediatric population.
MedLine Citation:
PMID:  21699121     Owner:  NLM     Status:  MEDLINE    
Symptomatic dermatographism reflects an exaggerated cutaneous response to the physical stimulus of pressure. Some consider it a common type of childhood physical urticaria. Its etiology can vary widely from drug reactions and infectious agents to systemic diseases and genetic inheritance. The mechanism is thought to be related to histamine degranulation due to a mechano-immunologic trigger, leading to the common symptoms of pruritus and burning in areas exposed to increased pressure, such as tight clothing, belts, and waistbands. The diagnosis typically is made with a blunt object such as a tongue blade or unopened ball-point pen pressed along the back and/or forearm, which elicits urtication. The mainstay of treatment is H1- and H2-receptor antagonists but also can include immunosuppressive agents, steroids, and phototherapy for refractory or severe cases.
Christopher A Mecoli; Aaron Joseph Morgan; Robert A Schwartz
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cutis     Volume:  87     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-06-24     Completed Date:  2011-07-12     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  221-5     Citation Subset:  IM    
Department of Dermatology, New Jersey Medical School, Newark, NJ 07103, USA.
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MeSH Terms
Histamine / metabolism
Histamine H1 Antagonists / pharmacology
Histamine H2 Antagonists / pharmacology
Physical Stimulation / adverse effects
Skin Diseases / etiology*,  pathology,  therapy
Urticaria / etiology*,  therapy
Reg. No./Substance:
0/Histamine H1 Antagonists; 0/Histamine H2 Antagonists; 51-45-6/Histamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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