Document Detail

Symptomatic arrhythmias due to syringomyelia-induced severe autonomic dysfunction.
MedLine Citation:
PMID:  24847769     Owner:  NLM     Status:  Publisher    
Syringomyelia is characterized by cavity formation in the spinal cord, most often at C2-Th9 level. Clinical manifestation reflects extent and localization of the spinal cord injury. Cases: 20-year old woman was admitted for recurrent rest-related presyncopes with sudden manifestation. Paroxysms of sinus bradycardia with SA and AV blocks were repeatedly documented during symptoms. There was normal echocardiographic finding, (para) infectious etiology was not proved. Character of the ECG findings raised suspicion on neurogenic cause. Autonomic nervous system testing demonstrated abnormalities reflecting predominant sympathetic dysfunction. Suspicion on incipient myelopathy was subsequently confirmed by MRI, which discovered syringomyelia at Th5 level as the only pathology. A 52-year old man with hypotrophic quadruparesis resulting from perinatal brain injury was sent for 2-years lasting symptoms (sudden palpitation, sweating, muscle tightness, shaking) with progressive worsening. Symptoms occurred in association with sudden increase of sinus rhythm rate and blood pressure that were provoked by minimal physical activity. Presence of significant autonomic dysregulation with baroreflex hyperreactivity in orthostatic test and symptomatic postural orthostatic tachycardia with verticalization-associated hypertension were proved. MRI revealed syringomyelia at C7 and Th7 level affecting sympathetic centers at these levels. Sympathetic fibers dysfunction at C-Th spinal level may cause significant autonomic dysfunction with arrhythmic manifestation.
Lucie Riedlbauchová; Tomáš Nedělka; Jakub Schlenker
Related Documents :
12074359 - Effects of omapatrilat on the renin-angiotensin system in salt-sensitive hypertension.
8897949 - Control of renal and mesenteric conductance during hemorrhage in conscious hypertensive...
1146999 - Role of angiotensin ii in experimental renal hypertension in the rabbit.
15076159 - Role of nad(p)h oxidase on vascular alterations in angiotensin ii-infused mice.
6684189 - Inhibitory action of prostaglandin e on angiotensin ii-induced enhancement of vasoconst...
2619419 - Role of endothelium in the secondary relaxation following contraction by various agonis...
16179049 - Accuracy of central venous pressure monitoring during simultaneous continuous infusion ...
4052729 - Comparison of the cardiovascular effects of meptazinol and naloxone following haemorrha...
21120299 - Associations of exposure to noise with physiological and psychological outcomes among p...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-22
Journal Detail:
Title:  Clinical research in cardiology : official journal of the German Cardiac Society     Volume:  -     ISSN:  1861-0692     ISO Abbreviation:  Clin Res Cardiol     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264123     Medline TA:  Clin Res Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Babies, soft drinks and snacks: a concern in low- and middle-income countries?
Next Document:  Distinct Electronic Structure of the Electrolyte Gate Induced Conducting Phase in Vanadium Dioxide R...