Document Detail


Symptomatic acquired zinc deficiency in at-risk premature infants: high dose preventive supplementation is necessary.
MedLine Citation:
PMID:  20653858     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Zinc is a cofactor for several enzymes involved in many metabolisms. Zinc deficiency induces various disorders such as acrodermatitis enteropathica, either inherited or acquired. We report three cases of premature infants (24-31 wks gestational age) with low birthweight (650 to 940 g) and enteropathy, two of whom presented with necrotizing enterocolitis. All infants were fed by total parenteral nutrition. At a chronological age ranging from 73 to 80 days, all infants developed a periorificial dermatitis. Before the onset of the first signs, they had received zinc supplementation ranging from 146% to 195% of the recommended dose (400 microg/kg/day). Increased zinc supplementation over a course of 6-18 days induced a complete resolution of symptoms in all cases. No abnormality in the neurologic examination and no recurrence were observed at the end of the zinc treatment. Low birthweight premature infants with enteropathy on total parenteral nutrition are at risk of developing zinc deficiency. The usual recommended zinc supplementation is probably insufficient for those infants. A delay in the diagnosis of zinc deficiency may lead to severe complications.
Authors:
Sébastien Barbarot; Emilie Chantier; Alice Kuster; Muriel Hello; Jean-Christophe Roze; Eric Blouin; Jean-François Stalder
Related Documents :
7185848 - Serum copper and ceruloplasmin in preterm infants: prospective study.
12050988 - Impact of maternal anemia on the infant's iron status at 9 months of age.
7324778 - The concentrations of trace elements in blood from healthy newborn infants.
7101408 - Riboflavin status in infants born in rural gambia, and the effect of a weaning food sup...
11903938 - Management of general anaesthesia in infants and children with a history of idiopathic ...
16527428 - Parental selection: a third selection process in the evolution of human hairlessness an...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric dermatology     Volume:  27     ISSN:  1525-1470     ISO Abbreviation:  Pediatr Dermatol     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406799     Medline TA:  Pediatr Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  380-3     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Nantes University Hospital, Nantes, France. sebastien.barbarot@chu-nantes.fr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nevus comedonicus syndrome-nevus comedonicus associated with ipsilateral polysyndactyly and bilatera...
Next Document:  Oral melanoacanthoma in an adolescent.