Document Detail

Symptomatic acquired zinc deficiency in at-risk premature infants: high dose preventive supplementation is necessary.
MedLine Citation:
PMID:  20653858     Owner:  NLM     Status:  In-Process    
Zinc is a cofactor for several enzymes involved in many metabolisms. Zinc deficiency induces various disorders such as acrodermatitis enteropathica, either inherited or acquired. We report three cases of premature infants (24-31 wks gestational age) with low birthweight (650 to 940 g) and enteropathy, two of whom presented with necrotizing enterocolitis. All infants were fed by total parenteral nutrition. At a chronological age ranging from 73 to 80 days, all infants developed a periorificial dermatitis. Before the onset of the first signs, they had received zinc supplementation ranging from 146% to 195% of the recommended dose (400 microg/kg/day). Increased zinc supplementation over a course of 6-18 days induced a complete resolution of symptoms in all cases. No abnormality in the neurologic examination and no recurrence were observed at the end of the zinc treatment. Low birthweight premature infants with enteropathy on total parenteral nutrition are at risk of developing zinc deficiency. The usual recommended zinc supplementation is probably insufficient for those infants. A delay in the diagnosis of zinc deficiency may lead to severe complications.
Sébastien Barbarot; Emilie Chantier; Alice Kuster; Muriel Hello; Jean-Christophe Roze; Eric Blouin; Jean-François Stalder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric dermatology     Volume:  27     ISSN:  1525-1470     ISO Abbreviation:  Pediatr Dermatol     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406799     Medline TA:  Pediatr Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  380-3     Citation Subset:  IM    
Department of Dermatology, Nantes University Hospital, Nantes, France.
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