Document Detail

Symptomatic Chiari type I malformation after radiation therapy in an infant: case report.
MedLine Citation:
PMID:  17415188     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: One previous case report has described the development of a Chiari I malformation in a child after fractionated radiation therapy to the anterior cranial base. The authors present an additional case of a 17-month-old girl treated for an isolated, malignant, rhabdoid tumor of the right neck with neoadjuvant chemotherapy, surgical exploration, and radiation therapy. CLINICAL PRESENTATION: The patient developed a Chiari I malformation and cervical syringomyelia 1.5 years after the treatment. The patient experienced two episodes of unresponsiveness before diagnosis, and the malformation was then identified on magnetic resonance imaging scans. INTERVENTION: Suboccipital decompressive craniectomy, and C1 laminectomy with autologous duraplasty were performed. RESULTS: Postoperative magnetic resonance imaging scans revealed reconstitution of cerebrospinal fluid at the foramen magnum and ascent of the cerebellar tonsils. The patient remains asymptomatic 5.5 years after treatment. CONCLUSION: The importance of this association is discussed in the context of the increasing use of radiation therapy in young children and infants.
Caitlin E Hoffman; Eric Lis; Suzanne L Wolden; Mark M Souweidane
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurosurgery     Volume:  60     ISSN:  1524-4040     ISO Abbreviation:  Neurosurgery     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-06     Completed Date:  2007-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E782; discussion E782     Citation Subset:  IM    
Department of Neurological Surgery, Weill Medical College of Cornell University, New York, New York 10021, USA.
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MeSH Terms
Arnold-Chiari Malformation / etiology*,  surgery*
Cerebellar Diseases / etiology,  surgery*
Cervical Vertebrae / surgery
Decompression, Surgical
Radiation Injuries / etiology,  surgery*
Radiotherapy / adverse effects*
Syringomyelia / etiology*,  surgery*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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