| Symptomatic carotid artery stenosis: impairment of cerebral autoregulation measured at the brain tissue level with arterial spin-labeling MR imaging. | |
| | |
MedLine Citation:
|
PMID: 20574097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To measure the cerebral autoregulatory status of the brain tissue supplied by the individual brain-feeding arteries in patients with symptomatic stenosis of the internal carotid artery (ICA) by using arterial spin-labeling (ASL) magnetic resonance (MR) imaging and to compare this status with that in healthy controls. MATERIALS AND METHODS: Institutional review board approval and informed consent were obtained. Twenty-three patients (mean age, 69.3 years +/- 8.0 [standard deviation]) with unilateral symptomatic stenosis of the ICA and 20 healthy controls (mean age, 66.8 years +/- 6.3 [standard deviation]) underwent perfusion and flow territory-selective ASL MR imaging before and after intravenous administration of acetazolamide. Cerebrovascular reactivity was measured throughout the brain in the gray matter that is supplied by the individual ICAs and the basilar artery. Data were analyzed with paired and unpaired t tests. RESULTS: In patients with symptomatic stenosis of the ICA, the flow territory of the symptomatic ICA was smaller than that of the asymptomatic ICA. After administration of acetazolamide, a significant increase in cerebral blood flow at the brain tissue level was measured in both control subjects and patients in all perfusion territories. Mean cerebrovascular reactivity values were 35.9% +/- 3.0% (standard error) and 44.6% +/- 3.5% (standard error) in the flow territories of the patients with symptomatic ICAs and those with asymptomatic ICAs, respectively, and 47.9% +/- 3.1% (standard error) in the control subjects. Cerebrovascular reactivity was lower in the flow territory of the symptomatic ICA than in the arteries of control participants (mean difference, -12.0%; 95% confidence interval: -20.7%, -3.3%). CONCLUSION: In patients with symptomatic stenosis of the ICA, vasodilatory capacity in the flow territories of the major cerebral arteries can be visualized and quantified at the brain tissue level with ASL MR imaging. |
| | |
Authors:
|
Reinoud P H Bokkers; Matthias J P van Osch; H Bart van der Worp; Gert J de Borst; Willem P T M Mali; Jeroen Hendrikse |
Related Documents
:
|
11074207 - Relation of nonobstructive aortic valve calcium to carotid arterial atherosclerosis. 15796397 - Use of an embolic protection system during endovascular recanalization of a totally occ... 21809967 - Role of 5-lipoxygenase pathway in the pathophysiology of the aortic stenosis. 16828427 - Natural history of carotid artery occlusion contralateral to carotid endarterectomy. 23225737 - With the back against the wall: tavi in a patient with endocarditis. 9361927 - Hepatic arterial complications in pediatric segmental liver transplantations from livin... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Radiology Volume: 256 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-24 Completed Date: 2010-07-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
|
Languages: eng Pagination: 201-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Radiology, University Medical Center Utrecht, HP E.01.132, Heidelberglaan 100, Utrecht, the Netherlands. r.p.h.bokkers@umcutrecht.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetazolamide
/
administration & dosage Aged Blood Flow Velocity / physiology Carbonic Anhydrase Inhibitors / administration & dosage Carotid Stenosis / physiopathology* Case-Control Studies Cerebrovascular Circulation / physiology Cerebrovascular Disorders / physiopathology* Chi-Square Distribution Female Humans Least-Squares Analysis Magnetic Resonance Angiography Magnetic Resonance Imaging / methods* Male Middle Aged Spin Labels* |
| Chemical | |
Reg. No./Substance:
|
0/Carbonic Anhydrase Inhibitors; 0/Spin Labels; 59-66-5/Acetazolamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Temporomandibular Joint Findings in Adults with Long-standing Juvenile Idiopathic Arthritis: CT and ...
Next Document: Intracranial Dural Arteriovenous Fistulas: Diagnosis and Evaluation with 64-Detector Row CT Angiogra...