Document Detail


Symptom-pattern phenotype and pulmonary function in preschool wheezers.
MedLine Citation:
PMID:  20579717     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pulmonary function in preschool wheezing phenotypes based on wheeze onset and duration and atopic status has been extensively described but has not been studied in symptom-pattern phenotypes of episodic (viral) and multiple-trigger wheeze. OBJECTIVE: We investigated whether multiple-trigger wheezers were more likely to have abnormal pulmonary function and increased fraction of exhaled nitric oxide (FeNO) than episodic (viral) wheezers and whether multiple-breath wash-out was more sensitive at detecting abnormal pulmonary function than specific airways resistance (sR(aw)) in preschool wheezers. METHODS: FeNO, multiple-breath wash-out indices (lung clearance index [LCI] and conductive airways ventilation inhomogeneity [S(cond)]) and sR(aw) were measured in healthy children and those with recurrent wheeze aged 4 to 6 years. Subgroup analysis was performed according to current symptom-pattern (multiple-trigger vs episodic [viral]), atopic status (atopic vs nonatopic), and wheeze status (currently symptomatic vs asymptomatic). RESULTS: Seventy-two control subjects and 62 wheezers were tested. Multiple-trigger wheezers were associated with an average increase of 11% (95% CI, 7% to 18%; P < .001) in LCI, 211% (95% CI, 70% to 470%; P < .001) in S(cond), and 15% (95% CI, 3% to 28%; P = .01) in sR(aw) compared with episodic (viral) wheezers. Pulmonary function in episodic (viral) wheezers did not differ significantly from control subjects. The presence of current atopy or wheeze was associated with higher FeNO (P = .05) but did not influence pulmonary function significantly. On average, LCI was abnormal in 39% (95% CI, 32% to 45%), S(cond) was abnormal in 68% (95% CI, 61% to 74%), and sR(aw) was abnormal in 26% (95% CI, 16% to 35%) of multiple-trigger wheezers. CONCLUSIONS: Multiple-trigger wheeze is associated with pulmonary function abnormalities independent of atopic and current wheeze status. S(cond) is the most sensitive indicator of abnormal pulmonary function in preschool wheezers.
Authors:
Samatha Sonnappa; Cristina M Bastardo; Angela Wade; Sejal Saglani; Sheila A McKenzie; Andrew Bush; Paul Aurora
Related Documents :
17962367 - Roles of t lymphocytes in pulmonary fibrosis.
3107147 - The inferior alveolar artery in its bony course.
7609007 - Fibrogenic potentials of coal slags used as abrasive blasting substitutes.
1261317 - Pulmonary fibrosis associated with tracheobronchial aspiration. a study of the frequenc...
2475727 - Palliative percutaneous aortic balloon valvuloplasty before noncardiac operations and i...
9178157 - Source of cerebral microembolic signals in occlusion of the internal carotid artery.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-25
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  126     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  519-26.e1-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Affiliation:
Portex Unit, Respiratory Medicine and Physiology, UCL Institute of Child Health, London, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Age of Onset
Child
Child, Preschool
Female
Humans
Linear Models
Lung Diseases / complications*,  physiopathology*
Male
Nitric Oxide / metabolism
Phenotype*
Reference Standards
Respiratory Function Tests
Respiratory Hypersensitivity / virology
Respiratory Sounds* / etiology
Sensitivity and Specificity
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide
Comments/Corrections
Comment In:
J Allergy Clin Immunol. 2010 Sep;126(3):489-90   [PMID:  20816185 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gene-environment interactions influence airways function in laboratory animal workers.
Next Document:  Indoor pet exposure and the outcomes of total IgE and sensitization at age 18 years.