| Symptom and joint mobility progression in the joint hypermobility syndrome (Ehlers-Danlos syndrome, hypermobility type). | |
| | |
MedLine Citation:
|
PMID: 22133089 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: To evaluate progression of symptoms and joint mobility in the joint hypermobility syndrome (JHS) in order to identify specific disease pictures by age at presentation. METHODS: Fifty JHS patients (44 females, 6 males) were evaluated by Beighton score (BS) calculation, and presence/absence and age at onset of 20 key symptoms. Incidence and prevalence rates by age at onset and sex were calculated and compared by chi-square, Fisher's exact test and Mann-Whitney U-test. Relationship between BS and age at examination was evaluated by the Spearman rho correlation. The existence of an age cut-off separating patients with or without a positive BS was analysed by the receiver operating characteristic analysis. Influence of age on the single components of the BS was also investigated. RESULTS: Except for isolated features, the overall clinical presentation was the same between sexes. In the whole sample, statistically significant differences by age at presentation were registered for fatigue, myalgias, muscle cramps, strains/sprains, dislocations, tendon ruptures, tendonitis, gastroesophageal reflux, chronic gastritis, constipation/diarrhoea and abdominal hernias. A clear inverse correlation between age at examination and BS was demonstrated with an age cut-off fixed at 33 years. Among the components of the BS, spine and elbow joints were not significantly influenced by age. CONCLUSIONS: This study confirmed the existence of a protean clinical history of JHS which may be exemplified in different phases with distinguishable presentations. The knowledge of the peculiarities of each of them will help the practitioner in recognising and, hopefully, treating this condition. |
| | |
Authors:
|
Marco Castori; Isabella Sperduti; Claudia Celletti; Filippo Camerota; Paola Grammatico |
Related Documents
:
|
21573849 - Sex assessment using odontometry and cranial anthropometry: evaluation in an indian sam... 11882349 - Relationship between cadmium concentration in rice and renal dysfunction in individual ... 8404839 - Evaluation of workload in air traffic controllers. 2667099 - Advancing age and acute infection influence the kinetics of ceftazidime. 22155319 - Fetal exposure to propoxur and abnormal child neurodevelopment at 2 years of age. 4028629 - Gastrointestinal absorption as a function of age: xylose absorption in healthy adults. 8148669 - Apparent velocity of ultrasound (avu) at the patella in comparison to bone mineral dens... 18375949 - Impact of body mass index on incident hypertension and diabetes in chinese asians, amer... 10640119 - Knowledge and attitudes of children towards cigarette smoking and its damage. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-30 |
Journal Detail:
|
Title: Clinical and experimental rheumatology Volume: - ISSN: 0392-856X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-12-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Medical Genetics, Department of Molecular Medicine, Sapienza University, San Camillo-Forlanini Hospital, Rome, Italy. mcastori@scamilloforlanini.rm.it. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vapour phase: a potential future use for essential oils as antimicrobials?
Next Document: Effect of persistent patent ductus arteriosus on mortality and morbidity in very low birth weight in...